Overview

This is a review of the methods for characterizing bioadhesive materials and for improving vehicle targeting and uptake - offering possibilities for reformulating existing compounds to create new pharmaceuticals at lower development costs. It evaluates the unique carrier characteristics of bioadhesive polymers and their power to enhance localization of delivered agents, local bioavailability, and drug absorption and transport.

Full Product Details

Author:   Edith Mathiowitz ,  Donald E. Chickering III ,  Claus-Michael Lehr ,  Claus-Michael Lehr
Publisher:   Taylor & Francis Inc
Imprint:   CRC Press Inc
Volume:   v98
Dimensions:   Width: 15.20cm , Height: 3.20cm , Length: 22.90cm
Weight:   1.224kg
ISBN:  

9780824719951

ISBN 10:   0824719956
Pages:   696
Publication Date:   13 July 1999
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Fundamentals of Bioadhesion Definitions, Mechanisms, and Theories of Bioadhesion Donald E. Chickering III and Edith Mathiowitz The Role of Water Movement and Polymer Hydration in Mucoadhesion John D. Smart A Rheological Approach to Explain the Mucoadhesive Behavior of Polymer Hydrogels Carla Marcella Caramella, Silvia Rossi, and Maria Cristina Bonferoni Functional Histology of Epithelia Relevant for Drug Delivery: Respiratory Tract, Digestive Tract, Eye, Skin, and Vagina Udo Schumacher and Dietlind Schumacher Biochemical and Functional Aspects of Mucus and Mucin-Type Glycoproteins Barry James Campbell Methods of Evaluating Bioadhesive Interactions Adaptation of a Microbalance to Measure Bioadhesive Properties of Microspheres Donald E. Chickering III, Camilla A. Santos, and Edith Mathiowitz Novel Magnetic Technique to Measure Bioadhesion Benjamin A. Hertzog and Edith Mathiowitz Principles of Skin Adhesion and Methods for Measuring Adhesion of Transdermal Systems Michael Horstmann, Walter Müller, and Bodo Asmussen Force Microscopy of Cells to Measure Bioadhesion E. zur Mühlen, P. Koschinski, S. Gehring, Robert Ros, Louis Tiefenhauer, Eleonore Haltner, Claus-Michael Lehr, Uwe Hartmann, Falk Schwesinger, and A. Plückthun Direct Measurement of Molecular-Level Forces and Adhesion in Biological Systems James Schneider and Matthew Tirrell A Centrifugation Method for Measurement of Two-Dimensional Binding Characteristics of Receptor-Ligand Interaction Cheng Zhu, James W. Piper, and Robert A. Swerlick Novel Concepts and Strategies for Bioadhesive Drug Delivery Systems Multifunctional Polymers for the Peroral Delivery of Peptide Drugs Henrik L. Luessen, J. Coos Verhoef, A. (Bert) G. de Boer, H. E. Junginger, Bas J. de Leeuw, Gerrit Borchard, and Claus-Michael Lehr Chitosan and Chitosan Derivatives as Absorption Enhancers for Peptide Drugs Across Mucosal Epithelia A. F. Kotzé, Henrik L. Luessen,

Reviews

This comprehensive, multi-author volume would form an excellent starting point for researchers, students and industrial scientists keen to familiarize themselves with this field. This book, a welcome addition to the series 'Drugs and the Pharmaceutical Sciences', will provide excellent background and, indeed, might almost be regarded as a manual for those working in this areas. - Retinoids & Lipid-Soluable Vitamins in Clinical Practice excellent. very interesting and certainly stimulating. The authors and the editors are to be congratulated for providing a valuable and timely review of a new development subject. -Pharmaceutical Technology

Author Information

Edith Mathiowitz, Donald E. Chickerin III, Claus-Michael Lehr

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