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Author:   Michael C Joiner (Wayne State University, Detroit, USA) ,  Albert van der Kogel (University of Wisconsin, Madison, USA)
Publisher:   Taylor & Francis Ltd
Imprint:   CRC Press
Edition:   6th edition
ISBN:  

9781032243818

ISBN 10:   1032243813
Pages:   340
Publication Date:   23 December 2024
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Forthcoming
Availability:   Not yet available  
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Table of Contents

Preface About the editors List of contributors Glossary 1. Introduction: The significance of radiobiology and radiotherapy for cancer treatment. 2. Irradiation-induced damage and the DNA damage response. 3. Cell death after irradiation – how, when and why cells die. 4. Quantifying cell kill and cell survival. 5. Radiation dose-response relationships. 6. Linear energy transfer and relative biological effectiveness. 7. Physics of radiation therapy for the radiobiologist. 8. Tumour growth and response to radiation. 9. Fractionation: The Linear-Quadratic approach. 10. The linear-quadratic approach in clinical practice. 11. Modified fractionation. 12. Early effects in epithelial tissues, the role of stem cells and time factors. 13. The dose-rate effect. 14. Pathogenesis of late normal tissue effects. 15. Volume effects, regional responses, and risk models. 16. Biological modifiers of normal tissue effects. 17. The oxygen effect and therapeutic approaches to tumour hypoxia. 18. The tumour microenvironment and cellular hypoxia responses. 19. Combined radiotherapy and chemotherapy from the perspective of the Radiation Oncologist. 20. Molecular targeted agents for enhancing tumour response. 21. Biological individualisation of radiotherapy. 22. Molecular image guided radiotherapy. 23. Retreatment tolerance of normal tissues. 24. Cancer stem cells in radiotherapy. 25. Hadron therapy: The clinical aspects. 26. Radiation and the immune system. 27. Second cancers after radiotherapy. Index

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Author Information

Michael C Joiner, PhD is a founding teacher and previous Course Director of the Basic Clinical Radiobiology Course at ESTRO, and Advisor and Teacher of Clinical Radiobiology at Wayne State University, Detroit, Michigan, USA. Albert J van der Kogel, PhD is a founding teacher and previous Course Director of the Basic Clinical Radiobiology Course at ESTRO, and Advisor and Teacher of Clinical Radiobiology at the University of Wisconsin, Madison, Wisconsin, USA.

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