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OverviewFull Product DetailsAuthor: Michael C Joiner (Wayne State University, Detroit, USA) , Albert van der Kogel (University of Wisconsin, Madison, USA)Publisher: Taylor & Francis Ltd Imprint: CRC Press Edition: 6th edition ISBN: 9781032243801ISBN 10: 1032243805 Pages: 340 Publication Date: 23 December 2024 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Forthcoming Availability: Not yet available This item is yet to be released. You can pre-order this item and we will dispatch it to you upon its release. Table of ContentsPreface About the editors List of contributors Glossary 1. Introduction: The significance of radiobiology and radiotherapy for cancer treatment. 2. Irradiation-induced damage and the DNA damage response. 3. Cell death after irradiation – how, when and why cells die. 4. Quantifying cell kill and cell survival. 5. Radiation dose-response relationships. 6. Linear energy transfer and relative biological effectiveness. 7. Physics of radiation therapy for the radiobiologist. 8. Tumour growth and response to radiation. 9. Fractionation: The Linear-Quadratic approach. 10. The linear-quadratic approach in clinical practice. 11. Modified fractionation. 12. Early effects in epithelial tissues, the role of stem cells and time factors. 13. The dose-rate effect. 14. Pathogenesis of late normal tissue effects. 15. Volume effects, regional responses, and risk models. 16. Biological modifiers of normal tissue effects. 17. The oxygen effect and therapeutic approaches to tumour hypoxia. 18. The tumour microenvironment and cellular hypoxia responses. 19. Combined radiotherapy and chemotherapy from the perspective of the Radiation Oncologist. 20. Molecular targeted agents for enhancing tumour response. 21. Biological individualisation of radiotherapy. 22. Molecular image guided radiotherapy. 23. Retreatment tolerance of normal tissues. 24. Cancer stem cells in radiotherapy. 25. Hadron therapy: The clinical aspects. 26. Radiation and the immune system. 27. Second cancers after radiotherapy. IndexReviewsAuthor InformationMichael C Joiner, PhD is a founding teacher and previous Course Director of the Basic Clinical Radiobiology Course at ESTRO, and Advisor and Teacher of Clinical Radiobiology at Wayne State University, Detroit, Michigan, USA. Albert J van der Kogel, PhD is a founding teacher and previous Course Director of the Basic Clinical Radiobiology Course at ESTRO, and Advisor and Teacher of Clinical Radiobiology at the University of Wisconsin, Madison, Wisconsin, USA. Tab Content 6Author Website:Countries AvailableAll regions |