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Author:   Sangsu Bae ,  Beomjong Song
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   1st ed. 2023
Volume:   2606
Weight:   0.671kg
ISBN:  

9781071628782

ISBN 10:   107162878
Pages:   235
Publication Date:   03 January 2023
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Part I: Overview of BEs, Diverse Variants of BEs, and Computational Tools for Bes   1. Introduction and Perspectives of DNA Base Editors             Beomjong Song and Sangsu Bae   2. Web-Based Computational Tools for Base Editors             Gue-Ho Hwang and Sangsu Bae   3. Prediction of Base Editing Efficiencies and Outcomes Using DeepABE and DeepCBE             Jinman Park and Hui Kwon Kim   4. Profiling Genome-Wide Specificity of dCpf1 Cytidine Base Editors Using Digenome-Seq             Daesik Kim   Part II: Application of BEs for Disease Modeling   5. Base Editing of Human Hematopoietic Stem Cells             Jing Zeng, Gabriele Casirati, My Anh Nguyen, Pietro Genovese, and Daniel E. Bauer   6. A/C Simultaneous Conversion Using the Dual Base Editor in Human Cells             Xiaohui Zhang, Yuting Guan, and Dali Li   7. Functional Analysis of Variants in BRCA1 Using CRISPR Base-Editors             Ji-Eun See and Yongsub Kim   8. Use of the Representative Base Editing Tool Target-AID to Introduce Pathogenic Mutations into Mice             Hiroki Sasaguri   9. Targeted Mutagenesis in Mice Using a Base Editor             Tae Yeong Jeong, Soo-Yeon Lim, Je Kyung Seong, and Kyoungmi Kim   Part III: Therapeutic Base Editing Strategies   10. Heterologous Expression and Purification of a CRISPR-Cas9-Based Adenine Base Editor             Seu-Na Lee, Hong-Su Jang, and Jae-Sung Woo   11. Delivering Base Editors In Vivo by Adeno-Associated Virus Vectors             Colin K.W. Lim, Angelo J. Miskalis, Pablo Perez-Pinera, and Thomas Gaj   12. The Delivery of ABE mRNA to the Adult Murine Liver by Lipid Nanoparticles (LNPs)             Dong Yang and Chun-Qing Song   13. Ex Vivo Base Editing Therapy with Chemically-Derived Hepatic Progenitors             Yohan Kim, Jaemin Jeong, and Dongho Choi   14. Application of Base Editor-Mediated Genome Editing in Mouse Retina             Jun Wu, Chang Sik Cho, Dong Hyun Jo, and Jeong Hun Kim   Part IV: Use of BEs in Plants and Bacteria   15. High-Throughput Base-Editing-Mediated Artificial Evolution Streamlines Trait Gene Identification in Rice             Fang Yan, Man Yu, Meixia Wang, and Huanbin Zhou   16. Heritable Virus-Induced Genome Editing (VIGE) in Nicotiana attenuate             Hyeonjin Kim, Youngbin Oh, Eunae Park, Moonyoung Kang, Yuri Choi, and Sang-Gyu Kim   17. Cytosine Base Editing in Bacteria             Ye Liu, Yang Liu, Ping Zheng, Yu Wang, and Meng Wang

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