Overview

The bacterial lipopolysaccharide also known as endotoxin is exhaustively covered in the present work. Central emphasis is placed upon the fine chemical structure of the lipopolysaccharide and its significance for understanding their activity and function. In particular, the role it plays in the interaction of bacteria with other biological systems is examined. New aspects of their physicochemical biology are introduced and updates to the current knowledge concerning the lipopolysaccharide are provided. This important class of biomolecules has recently attracted the attention of many investigators, in particular for understanding its involvement in innate immunity, toll-like receptor recognition and intracellular signaling.

Full Product Details

Author:   Yuriy A. Knirel ,  Miguel A. Valvano
Publisher:   Springer Verlag GmbH
Imprint:   Springer Verlag GmbH
Dimensions:   Width: 15.50cm , Height: 3.30cm , Length: 23.50cm
Weight:   0.840kg
ISBN:  

9783709107324

ISBN 10:   3709107326
Pages:   440
Publication Date:   13 July 2011
Audience:   College/higher education ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us.

Table of Contents

-1. Lipid A structure (A. Silipo, A. Molinaro).- 2. Structure of the lipopolysaccharide core region (O. Holst).- 3. Structure of O-antigens (Y.A. Knirel).- 4. Chemical synthesis of lipid A and analogues (S. Kusumoto).- 5. Chemical synthesis of lipopolysaccharide core (P. Kosma, A. Zamyatina).- 6. Genetics and biosynthesis of lipid A (C.M. Stead, A.C. Pride, M.S. Trent).- 7. Pathways for the biosynthesis of NDP sugars (Y. Hao, J. Lam).- 8. Lipopolysaccharide core oligosaccharide biosynthesis and assembly (U. Mamat, M. Skurnik, J.A. Bengoechea).- 9. Genetics, biosynthesis and assembly of O-antigen (M.A. Valvano, S.E. Furlong, K.B. Patel).- 10. Lipopolysaccharide export to the outer membrane (P. Sperandeo, G. Dehò, A. Polissi).- 11. Evolution of lipopolysaccharide biosynthesis genes (M.M. Cunneen, P.R. Reeves).- 12. The molecular basis of lipid A and Toll-like receptor 4 interactions (G.L. Hold, C.E. Bryant).- 13. Modulation of lipopolysaccharide signalling through TLR4 agonists and antagonists (F. Peri, M. Piazza, V. Calabrese, R. Cighetti).- 14. Lipopolysaccharide interactions with plants (G. Erbs, M.-A. Newman)

Reviews

Author Information

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions