Overview

"In the seventeenth century, smallpox reigned as the world's worst killer. Luck, more than anything else, decided who would live and who would die. That is, until Lady Mary Wortley Montagu, an English aristocrat, moved to Constantinople and noticed the Turkish practice of ""ingrafting"" or inoculation, which, she wrote, made ""the small- pox...entirely harmless."" Convinced by what she witnessed, she allowed her six-year-old son to be ingrafted, and the treatment was a complete success--the young Montagu enjoyed lifelong immunity from smallpox. Lady Montagu's discovery would, however, remain a quiet one; it would be almost 150 years before inoculation (in the more modern form of vaccination) would become widely accepted while the medical community struggled to understand the way our bodies defend themselves against disease. William Clark's At War Within takes us on a fascinating tour through the immune system, examining the history of its discovery, the ways in which it protects us, and how it may bring its full force to bear at the wrong time or in the wrong place. Scientists have only gradually come to realize that this elegant defense system not only has the potential to help, as in the case of smallpox, but also the potential to do profound harm in health problems ranging from allergies to AIDS, and from organ transplants to cancer. Dr. Clark discusses the myriad of medical problems involving the immune system, and he systematically explains each one. For example, in both tuberculosis and AIDS, the underlying pathogens take up residence within the immune system itself, something Clark compares to having a prowler take up residence in your house, crawling around through the walls and ceilings while waiting to do you in. He discusses organ transplants, showing how the immune system can work far too well, and touching on the heated ethical debate over the use of both primate and human organs. He explores the mind's powerful ability to influence the performance of the immune system; and the speculation that women, because they have developed more powerful immune systems in connection with childbearing, are more prone than men to contract certain diseases such as lupus. In a fascinating chapter on AIDS, arguably the most deadly epidemic seen on Earth since the smallpox, Clark explains how the disease originated and the ways in which it operates. And, in each section, we learn about the most recent medical breakthroughs. At first glance, it may appear that our immune system faces daunting odds; it must learn to successfully fend off, not thousands, but millions of different types of microbes. Fortunately, according to Clark, it would be almost impossible to imagine a more elegant strategy for our protection than the one chosen by our immune system, and his At War Within provides a thorough and engaging explanation of this most complex and delicately balanced mechanism."

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9780195115680

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Reviews

Review from the cloth edition: The book could serve as good supplementary reading and should be in all libraries. Even professional immunologists will learn something. * Choice *

"""Clark's historical background and clear explanations of...microscopic processes offer the kind of primer that lay readers will find valuable.""--Business Week ""Explain[s] the rudiments of the immune system and the terrible consequences that can occur when the immune system is absent, as with AIDS, or when it is misguided, as with autoimmune diseases like lupus.... And there is a tantalizing section on the new discipline of psychoneuroimmunology--the relation of the mind to the immune system.""--Anna Fels, The New York Times Book Review ""Clark is an experienced teacher and researcher, and it shows. He communicates well and knows his subject.""--Choice ""Clark's historical background and clear explanations of...microscopic processes offer the kind of primer that lay readers will find valuable.""--Business Week ""A pithy overview...of the milestones in immunologic history and research.""--Discover ""A lucid discussion of our body's immune system. Devoting each chapter to a unique malady or condition, [Clark] provides the details needed to understand our immune structure, particularly when it unravels and turns on itself.... Clark's presentation is straightforward, arranged well, and includes historical background. Highly recommended.""--Library Journal ""Explain[s] the rudiments of the immune system and the terrible consequences that can occur when the immune system is absent, as with AIDS, or when it is misguided, as with autoimmune diseases like lupus.... And there is a tantalizing section on the new discipline of psychoneuroimmunology--the relation of the mind to the immune system.""--Anna Fels, The New York Times Book Review ""The immune system is a lifesaver, but it can overkill--that is, attack its possessor's friends as well as its enemies. Clark explains this highly technical subject clearly.""--Booklist ""A lucid, up-to-date account of the body's immune system from a pro who has taught the subject at UCLA for 25 years.""--Kirkus Reviews"

A lucid, up-to-date account of the body's immune system from a pro who has taught the subject at UCLA for 25 years. Infectious disease is news Big Time these days - it has been ever since AIDS appeared. What is fascinating is the game of catch-up that science has been playing - unraveling the intricacies of the body's immune system and, more recently, its intimate relation to the nervous system. Clark reminds us that just a generation ago the body's defenses were thought to consist only of antibodies: the molecules that destroy foreign invaders. Not only does Clark explain how the body can be stimulated, say, by vaccines, to make millions of antibodies, but he goes into detail about T cells - the other ann of the immune system. T cells (the T is for the thymus, where they are made) come in several varieties, of which the most noted today are the killer T cells that search and destroy aberrant cells and the CD4 helper T cells that are killed by the AIDS virus. Sometimes the immune system is overzealous, however, mounting an attack that adds insult and injury: There is a misreading of molecular markers, resulting in attacks on healthy cells, as happens in autoimmune diseases such as multiple sclerosis (the war within), and sometimes there is a need to suppress the system - in the case of organ transplants. Clark's upbeat outlook suggests that we can curb excesses as well as stimulate a weakened immune system with new drugs or gene therapy approaches. He is convinced that ongoing discoveries of the brain-immune system dialogue will lead to new approaches to therapy. He is also aware of the pressing need for organ transplants, raising provocative ethical issues but at the same time providing a valid Uniform Anatomical Gift Act donor card for readers to fill out. A good idea that, given his overall enthusiasm and mastery in explaining complex science, might persuade more than a few readers. (Kirkus Reviews)

Review from the cloth edition: The book could serve as good supplementary reading and should be in all libraries. Even professional immunologists will learn something. Choice

Author Information

William R. Clark, an internationally recognized authority on cellular immune responses, has taught immunology at the University of California, Los Angeles for the past twenty-five years. He is the author of Sex and the Origins of Death.

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