Overview

Full Product Details

Author:   Roger L. Lundblad
Publisher:   Taylor & Francis Inc
Imprint:   Chapman & Hall/CRC
Volume:   v. 2
Dimensions:   Width: 15.60cm , Height: 2.30cm , Length: 23.40cm
Weight:   0.635kg
ISBN:  

9781439807804

ISBN 10:   1439807809
Pages:   368
Publication Date:   15 December 2009
Audience:   College/higher education ,  General/trade ,  Tertiary & Higher Education ,  General
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us.

Table of Contents

Introduction to Biopharmaceutical Conformational Analysis: Issues and Methods. Comparability of Biotechnological/Biological Products and Biological Generics. Application of Native Electrophoresis for the Study of Protein Conformation. Affinity Chromatography Including Hydrophobic Interaction Chromatography in the Study of Biopolymer Conformation. Size-Exclusion Chromatography and Biomolecular Conformation. Use of Analytical Ultracentrifugation to Study Biomolecular Conformation. Use of Differential Scanning Calorimetry to Measure Conformational Change in Proteins and Other Biomacromolecules. Light Scattering and Biomacromolecular Conformation. Use of Luminescence to Measure Conformational Change in Biopharmaceuticals with Emphasis on Protein and Protein Drug Products. Near-Infrared Spectroscopy and Macromolecular Conformation. The Use of Mid-Infrared and Fourier Transform Infrared Spectroscopy to Study Conformation of Biomacromolecules. Use of Raman Spectroscopy to Evaluate Biopharmaceutical Conformation. Use of UV-VIS Spectrophotometry for the Characterization of Biopharmaceutical Products. Use of Optical Rotatory Dispersion and Circular Dichroism to Study Therapeutic Biomacromolecule Conformation. Use of Nuclear Magnetic Resonance for the Characterization of Biotherapeutic Products. Use of Chemical Probes for the Study of Protein Conformation. Use of Hydrogen Exchange in the Study of Biopharmaceutical Conformation. Use of Chemical Modifi cation for the Conformational Analysis of Biopharmaceuticals. Use of Immunology to Characterize Biopharmaceutical Conformation. Use of Limited Proteolysis to Study the Conformation of Proteins of Biotechnology Interest. Other Technologies for the Characterization of Conformational Change in Biopharmaceuticals. Development of an Experimental Approach for the Study of the Conformation of a Biological Therapeutic Product.

Reviews

Lundblad (pathology, U. of North Carolina at Chapel Hill) provides coverage of the range of technology used for the conformational analysis of biopharmaceutical polymers, intending to provide sufficient information and extensive references to establish the basis for the selection of a specific experimental approach that would be most cost-effective in the study of biopolymer conformation. Technologies addressed include native electrophoresis, affinity chromatography, size-exclusion chromatography, analytical ultracentrifugation, differential scanning calorimetry, light scattering, luminescence, near-infrared spectroscopy, mid-infrared and Fourier transform infrared spectroscopy, Raman spectroscopy, UV-VIS spectroscopy, optical rotatory dispersion and circular dichroism, nuclear magnetic resonance, chemical probes, hydrogen exchange, chemical modification,. immunology, and limited proteolysis --2010 Book News Inc. Portland, OR Without any hesitation, I recommend this book to any researcher Involved in the analysis of conformation and stability of biotechnology products (not necessarily limited to blopharmaceuticals). --Igor A Kaltashov. FUTURE SCIENCE. JULY 2010, VOL 2, No 8, pp 1361-1362

Author Information

After postdoctoral work at Rockefeller University, New York, Dr. Roger L. Lundblad joined the faculty of the University of North Carolina at Chapel Hill in 1968. He joined the Hyland division of Baxter Healthcare in 1990. Currently, he is an independent consultant and biotechnology writer based in Chapel Hill, North Carolina. He is an adjunct professor of pathology at the University of North Carolina at Chapel Hill and an editor in chief of the Internet Journal of Genomics and Proteomics.

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions