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OverviewThe new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new ways—an effort requiring funding, interagency coordination, and data management strategies. Table of Contents Front Matter Summary 1 Introduction 2 Toxicogenomic Technologies 3 Experimental Design and Data Analysis 4 Application to Exposure Assessment 5 Application to Hazard Screening 6 Application to Analyzing Variation in Human Susceptibility 7 Application to the Study of Mechanisms of Action 8 Other Potential Applications of Toxicogenomic Technologies to Risk Assessment 9 Validation 10 Sample and Data Collection and Analysis 11 Ethical, Legal, and Social Issues 12 Conclusions and Recommendations References Appendix A: Biographic Information on the Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology Appendix B: Minimum Information About a Microarray Experiment for Toxicogenomics Appendix C: Overview of Risk Assessment Full Product DetailsAuthor: National Research Council , Division on Earth and Life Studies , Board on Life Sciences , Board on Environmental Studies and ToxicologyPublisher: National Academies Press Imprint: National Academies Press Dimensions: Width: 15.20cm , Height: 1.80cm , Length: 22.90cm Weight: 0.476kg ISBN: 9780309112987ISBN 10: 0309112982 Pages: 300 Publication Date: 19 December 2007 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Out of stock  The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available. Table of Contents1 Front Matter; 2 Summary; 3 1 Introduction; 4 2 Toxicogenomic Technologies; 5 3 Experimental Design and Data Analysis; 6 4 Application to Exposure Assessment; 7 5 Application to Hazard Screening; 8 6 Application to Analyzing Variation in Human Susceptibility; 9 7 Application to the Study of Mechanisms of Action; 10 8 Other Potential Applications of Toxicogenomic Technologies to Risk Assessment; 11 9 Validation; 12 10 Sample and Data Collection and Analysis; 13 11 Ethical, Legal, and Social Issues; 14 12 Conclusions and Recommendations; 15 References; 16 Appendix A: Biographic Information on the Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology; 17 Appendix B: Minimum Information About a Microarray Experiment for Toxicogenomics; 18 Appendix C: Overview of Risk AssessmentReviewsAuthor InformationCommittee on Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment, National Research Council Tab Content 6Author Website:Countries AvailableAll regions |
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