Overview

There is genetic evidence that the type 4 allele of the apolipoprotein E gene is a major, susceptibility factor associated with late-onset Alzheimer's disease, the common form of the disease defined as starting after 60 years of age. This work presents the results concerning the implications of apoliprotein E on the genetics, cell biology, neuropathology, biochemistry and therapeutic management of Alzheimer's disease.

Full Product Details

Author:   A. D. Roses ,  K. H. Weisgraber ,  Yves Christen
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   illustrated edition
Weight:   0.450kg
ISBN:  

9783540607984

ISBN 10:   3540607986
Pages:   208
Publication Date:   03 May 1996
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Apolipoprotein E and Alzheimer's Disease: State of the Field After Two Years.- Role of Apolipoprotein E in Alzheimer's Disease: Clues from its Structure.- Apolipoprotein E4, Cholinergic Integrity, Synaptic Plasticity and Alzheimer's Disease.- Pattern of Apolipoprotein E Immunoreactivity During Brain Aging.- Apolipoprotein E: Structure, Function, and Possible Roles in Modulating Neurite Extension and Cytoskeletal Activity.- Apolipoprotein E Role in Maintaining the Integrity of the Aging Central Nervous System.- Very Low Density Lipoprotein Receptor and Alzheimer's Disease.- Apolipoprotein E and Apolipoprotein E Receptors in the Central Nervous System: Relationship with Alzheimer's Disease.- Tau Protein and the Neurofibrillary Pathology of Alzheimer's Disease.- Tau Protein and Alzheimer Paired Helical Filament Assembly: Interacting Domains and Control Residues.- The ssA4 Amyloid Peptide Enhances Cellular Uptake of Apolipoprotein E-Containing Lipoproteins by the Low-Density Lipoprotein Receptor-Related Protein/?2-Macroglobulin Receptor.- Interactions of Apolipoprotein E with Microtubule-Associated Proteins.- Chaperoning Amyloid in Alzheimer's Disease: The Art of Avoiding Sticky Situations?.- Apolipoprotein E Oxidation and Functional Consequences.- Ethnic Variation in the Association Between APOE-?4 and Alzheimer's Disease: A Follow-up Study.- The Search for Additional Alzheimer's Disease Genes.

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