Overview

This new edition of Antifungal Therapy aims at providing concise, practical, need-to-know information for busy physicians dealing with fungal infections, such as infectious disease physicians, transplant surgeons, dermatologists, and intensivists, as well as basic scientists and pharmaceutical company researchers interested in the state of antifungal therapy. It provides a comprehensive, up-to-date overview of the pertinent issues pertaining to antifungal treatment including the basics of clinical mycology, management insights for various infections, evidence-based treatment recommendations, and helpful tables summarizing currently available pharmacokinetics data. Key Features • Features useful information on administration, dosage and pharmacology of antifungal drugs that can be difficult to use in clinical practice • Contains common Clinical Questions & Answers to highlight frequently encountered patient issues • Covers clinical mycology essentials in addition to antifungal treatment to create a well-rounded reference • Presents illustrations and clinical photos in full color to elucidate the concepts • Provides detailed evidence of treatment recommendations

Full Product Details

Author:   Mahmoud A. Ghannoum, PhD, EMBA ,  John R. Perfect
Publisher:   Taylor & Francis Ltd
Imprint:   CRC Press
Edition:   2nd edition
Weight:   1.093kg
ISBN:  

9780367655945

ISBN 10:   0367655942
Pages:   524
Publication Date:   30 September 2020
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Preface Editors Contributors 1. History of antifungals Emily L. Larkin, Ali Abdul Lattif Ali, and Kim Swindell 2. Epidemiology of fungal infections: What, where, and when Frederic Lamoth, Sylvia F. Costa, and Barbara D. Alexander 3. Experimental animal models of invasive fungal infections Christopher L. Hager, Lisa Long, Yoshifumi Imamura, and Mahmoud A. Ghannoum 4. Antifungal drug resistance: Significance and mechanisms Sharvari Dharmaiah, Rania A. Sherif, and Pranab K. Mukherjee 5. Antifungal prophylaxis: An ounce of prevention is worth a pound of cure Aimee K. Zaas 6. Preemptive antifungal therapy: Do diagnostics help? Vidya Jagadeesan, Margaret Powers-Fletcher, and Kimberly E. Hanson 7. The immune response to fungal challenge Jeffery Hu and Jeffery J. Auletta 8. Immunomodulators: What is the evidence for use in mycoses? J. Andrew Alspaugh 9. Fungal biofilms and catheter-associated infections Jyotsna Chandra and Mahmoud A. Ghannoum 10. Polyenes for prevention and treatment of invasive fungal infections Richard H. Drew 11. Flucytosine Richard H. Drew 12. Pharmacology of azole antifungal agents Elizabeth S. Dodds Ashley 13. Echinocandins for prevention and treatment of invasive fungal infections Melissa D. Johnson, John Mohr, and Ahmad Mourad 14. Novel methods of antifungal administration Richard H. Drew 15. Dermatophytosis Mahmoud A. Ghannoum, Iman Salem, and Nancy Isham 16. Invasive candidiasis Richard R. Watkins and Tracy Lemonovich 17. Invasive aspergillosis Frank Esper 18. Management of cryptococcosis John R. Perfect and Ahmad Mourad 19. Management of endemic mycoses John R. Perfect and Ahmad Mourad 20. Human hyalohyphomycoses: A review of human infections due to Acremonium spp., Paecilomyces spp., Penicillium spp., Talaromyces spp., and Scopulariopsis spp. Nour Hasan 21. Management of phaeohyphomycosis John R. Perfect and Ahmad Mourad 22. Pneumocystis Kim Swindell 23. Management of mucormycoses John R. Perfect and Ahmad Mourad 24. Antifungal management in risk groups: Solid organ transplant recipients Jasmine Chung, Sylvia F. Costa, and Barbara D. Alexander 25. Prophylaxis and treatment of invasive fungal infections in neutropenic cancer and hematopoietic cell transplant patients Daniel R. Richardson, Marcie L. Riches, and Hillard M. Lazarus 26. Antifungal use in transplant recipients: Selection, administration, and monitoring Richard H. Drew, Mary L. Townsend, Melanie W. Pound, and Steven W. Johnson 27. Infants: Yeasts are beasts in early life Rachel G. Greenberg and Daniel K. Benjamin Jr. 28. Newer antifungal agents in pediatrics William J. Steinbach 29. Fungal infections in burn patients Nour Hasan 30. Allergic bronchopulmonary aspergillosis

Reviews

"""This book succeeds overall as an important reference and a comprehensive review of the current state of antifungal therapy in humans. The up-to-date information makes it a useful resource for clinicians consulting for immunosuppressed patients with invasive mycoses. The scientific data presented and the clinical experience and insight of the expert authors on the use of newer antifungal drugs in the pediatric population in the last section will be particularly useful in guiding practicing pediatricians in the care of their patients. Perhaps the last chapter is one of the most valuable of all, putting in perspective the mycobiome, which, as a part of the microbiome, plays a key role in health and disease."" Robert Gene Penn, MD (Nebraska Methodist Hospital)"

This book succeeds overall as an important reference and a comprehensive review of the current state of antifungal therapy in humans. The up-to-date information makes it a useful resource for clinicians consulting for immunosuppressed patients with invasive mycoses. The scientific data presented and the clinical experience and insight of the expert authors on the use of newer antifungal drugs in the pediatric population in the last section will be particularly useful in guiding practicing pediatricians in the care of their patients. Perhaps the last chapter is one of the most valuable of all, putting in perspective the mycobiome, which, as a part of the microbiome, plays a key role in health and disease. Robert Gene Penn, MD (Nebraska Methodist Hospital)

Author Information

Mahmoud A. Ghannoum, PhD, MBA, FIDSA, FAAM joined Case Western Reserve University and University Hospitals Case Medical Center in 1996 from prior positions at the UCLA School of Medicine and Kuwait University. Dr. Ghannoum has spent his entire academic career studying medically important fungi encompassing different fungal pathogens including Candida, Aspergillus, and Cryptococcus, the major causes of fungal infections. He has published more than 350 peer-reviewed articles addressing various aspects of superficial and systemic fungal infections. More recently, he published the first study describing the oral mycobiome of healthy individuals. He has published extensively in the area of fungal pathogenesis with special focus on virulence factors including phospholipase B, germination, adhesion, and biofilm formation, both in vitro and in vivo. Dr. Ghannoum is a professor and director of the Center for Medical Mycology at Case Western Reserve University and University Hospitals Case Medical Center. This center of excellence, which he directs, is a multidisciplinary center that combines basic and translational research investigating fungi from the test tube to the bedside. He has performed several studies investigating the mechanisms underlying Candida pathogenesis. He is the recipient of the Freedom to Discover Award from Bristol- Myers Squibb and the Rhoda Benham Award from the Medical Mycological Society of the Americas. He served as a chairman of the Subcommittee on Antifungal Susceptibility Testing, Clinical Laboratory Standards Institute, and was selected as a ""Most Interesting Person"" by Cleveland Magazine in 2013. Dr. Ghannoum is an entrepreneur-scientist who has launched a number of companies focusing on the treatment of biofilm infections and microbial dysbiosis as it relates to gut health. He coined the term ‘Mycobiome’. John R. Perfect, MD, is James B. Duke Professor of Medicine at Duke University Medical Center, a faculty member of the Duke University Interdisciplinary Program in Genetics, and director of the Duke University Mycology Research Unit. He is chief of the Division of Infectious Diseases in the Department of Medicine at Duke Medical Center. Dr. Perfect is a diplomat of the American Board of Internal Medicine and American Board of Infectious Diseases. After receiving an undergraduate degree in biology from Wittenberg University, Dr. Perfect went on to receive a medical degree from the Medical College of Ohio at Toledo. He then completed an internship at the Riverside Methodist Hospital in Columbus, Ohio; a residency in internal medicine at the University of Michigan Medical Center in Ann Arbor; and a fellowship in infectious diseases at Duke University Medical Center. He is a fellow of the American Society for Microbiology and the Infectious Diseases Society of America. Dr. Perfect is also a fellow of the American Association for Advancement of Science and member of International Society for Human and Animal Mycology, and Immunocompromised Host Society (ISHAM). He is president of the Mycoses Study Group and Educational Research Consortium and president-elect of ISHAM. Dr. Perfect has served on numerous committees and advisory boards. He received the Rhoda Benham Award from Medical Mycology Society of the Americas and the Lucille Georg Award from ISHAM. Dr. Perfect’s research interests focus on the understanding of fungal pathogenesis through the study of Cryptococcus neoformans as well as clinical studies on the epidemiology, diagnosis, and management of invasive mycoses.

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