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OverviewGram negative bacterial infections occur frequently - more than 300,000 hospitalized patients develop serious gram negative bacterial infections each year in the US. Mortality of gram negative bacterial serpsis is greater than 10% and exceeds 30% in immunocompressed patients. The failure of conventional therapy has provided an impetus for the development of new adjuvant treatment of gram negative bacterial infections, such as the use of antibodies directed against endotoxin and endotoxin-induced monokines. This book describes the development of these new approaches and their clinical implementations. Full Product DetailsAuthor: R.S. Burd , C.S. Cody , D.L. DunnPublisher: Taylor & Francis Inc Imprint: CRC Press Inc Weight: 0.604kg ISBN: 9781879702042ISBN 10: 1879702045 Pages: 150 Publication Date: 01 December 1992 Audience: College/higher education , Professional and scholarly , Undergraduate , Postgraduate, Research & Scholarly Format: Hardback Publisher's Status: Active Availability: In Print  This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of ContentsThe clinical problem; historical perspective; current epidemiology; clinical presentation and manifestations; definitions and classification; standard therapy of gram negative bacterial infections; structure of endotoxin; overview; outer polysaccharide; core polysaccharide; lipid a; host responses to endotoxin; pathophysiology of gram-negative bacterial infections; immune responses to endotoxin; new treatment modalities; historical perspective; therapeutic endotoxin clearance lipid A analogues; bactericidal/permeability-increasing protein; therapeutic blockade of cytokine responses; antibody immunotherapy of gram-negative bacterial sepsis; new directions.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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