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OverviewThoroughly detailed and illustrated, this book examines the construction, properties, applications, and problems associated with specific types of fusion molecules used in clinical and research medicine. The editors present an overview of the field, followed by nine chapters divided into two general sections based on the two primary parts of the antibody molecule: Fab fusion proteins and Fc fusion proteins. In addition, numerous renowned scientists in the field have contributed outlines demonstrating man-made molecules that will be required not only to overcome the limitations of monoclonal antibodies, but also to extend the principle of selective targeting. Divided into specific, accessible sections, Antibody Fusion Proteins includes: Chapters describing Fc fusion proteins, as well as several classes of antigen-binding proteins Complete details on the design and molecular construction of genetically engineered fusion molecules Useful information on molecular purification, large-scale production, practical applications, and their therapeutic potential The latest data on forming fusion proteins with toxins, cytokines, or enzymes that can activate a prodrug Full Product DetailsAuthor: Steven M. ChamowPublisher: John Wiley and Sons Ltd Imprint: John Wiley & Sons Inc Dimensions: Width: 16.00cm , Height: 2.70cm , Length: 24.00cm Weight: 0.680kg ISBN: 9780471183587ISBN 10: 047118358 Pages: 312 Publication Date: 13 April 1999 Audience: College/higher education , Professional and scholarly , Undergraduate , Postgraduate, Research & Scholarly Format: Hardback Publisher's Status: Out of Stock Indefinitely Availability: Out of stock  Table of ContentsOverview (S. Chamow A. Ashkenazi); Fab Fusion Proteins: Immunoligands (M. Penchent, et al. ); Immunoezymes (S. Rybak D. Newton); Recombinant Immunotoxins (D. Fitzgerald); F(ab')2 Fusion Proteins and Bispecific F(ab')2 (J. Tso); Monovalent Phage Display of Fab and seFv Fusions (D. Powers J. Marks); Bispecific Fusion Proteins (J. Goldstein, et al. ); Immunoglobin Fusion Proteins (A. Aruffo); TNF Receptor IgG Fusion Protein: Principles, Design, and Activities (W. Lesslauer); Optimizing Production and Recover of Immunoadhesins (S. Chamow, et al. ).ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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