Overview

Recombinant DNA techniques have revolutionized the isolation and production of antibodies in recent years, and rapid changes have been made. This new Practical Approach book details protocols which allow the researcher to isolate a new antibody, analyse its properties, format the right antibody molecule or fragment, and produce it in usable quantities.

Full Product Details

Author:   John McCafferty ,  Hennie Hoogenboom ,  Dave Chiswell (, all at Cambridge Antibody Technology Limited)
Publisher:   Oxford University Press
Imprint:   Oxford University Press
Volume:   169
Dimensions:   Width: 15.50cm , Height: 1.90cm , Length: 23.50cm
Weight:   0.522kg
ISBN:  

9780199635924

ISBN 10:   0199635927
Pages:   348
Publication Date:   27 June 1996
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   To order  
Stock availability from the supplier is unknown. We will order it for you and ship this item to you once it is received by us.

Table of Contents

1: Construction and use of antibody gene repertoires 2: Affinity maturation of antibodies using phage display 3: Human antibody repertoires in transgenic mice: manupulation and transfer of YACs 4: Measuring antibody affinities in solution 5: Measuring antibody affinities using Bio-sensors 6: Analysis of human antibody sequences 7: Rodent to human antibodies by CDR grafting 8: Rodent to human antibodies by phage display 9: Choosing and manipulating effector functions 10: Secretion and purification of antibody fragments expressed in bacteria 11: Production of single chain Fv monomers and multimers 12: Expression of immunoglobulin genes in mammalian cells 13: In vitro linkage of antibody fragments into dimeric and multimeric forms

Reviews

This resource is highly recommended for libraries and bookstores of academic, medical technology, and pharmaceutical institutions. --Doody's Health Sciences Book Review Home Page<br>

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