Overview

Anti-Aging Pharmacology provides an overview of current research aimed at the pharmacological modulation of aging including a discussion of the growing number of novel drug classes with promising anti-aging potential. The aging process is the main risk factor for all chronic diseases affecting the elderly. With lifespans extending across the globe, these chronic diseases are placing a larger burden on individuals and health care systems. Therefore, slowing down the aging rate could be more effective in delaying aging-associated chronic disorders than combating them one by one, which is the conventional approach in a current disease-based pharmacological paradigm. Different drug classes shown to have pro-longevity properties in experimental models are being increasingly developed and investigated in pre-clinical and clinical trials to determine whether they have anti-aging potential as well. This book contains work of the world's leading researchers in the field. It begins with the conceptual and methodological background of anti-aging pharmacology, explains the basic classes of anti-aging drugs, explores phytochemicals, and finally looks to outcomes of anti-aging developments and future directions. Anti-Aging Pharmacology will be of interest to a wide audience, ranging from pharmacologists, medicinal chemists, and academic researchers in gerontology, biomedical sciences, and those in medical practice.

Full Product Details

Author:   Alexander M. Vaiserman (Head of the Laboratory of Epigenetics, Institute of Gerontology, Kiev, Ukraine)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
ISBN:  

9780128236796

ISBN 10:   0128236795
Pages:   465
Publication Date:   01 September 2022
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Forthcoming
Availability:   Not yet available  
This item is yet to be released. You can pre-order this item and we will dispatch it to you upon its release.

Table of Contents

SECTION I. Conceptual and Methodological Backgrounds 1. Can Aging be Cured as a Disease? 2. Geroscience Conceipt 3. Mechanistic Pathways of Aging 4. Biomarkers of Aging Rate 5. Artificial Intelligence-Based Approach in Anti-Aging Pharmacology 6. Big Data Approach 7. OMICs Approaches SECTION II. Basic Classes of Anti-Aging Drugs 8. Antioxidant Paradox 9. Melatonin 10. Calorie Restriction Mimetics 11. Metformin 12. Rapamycin and rapalogs 13. Nonsteroidal Anti-Inflammatory Drugs 14. Statins 15. Senolytics 16. Epigenetic Drugs 17. Sirtuin Activating Compounds 18. Autophagy Inducers 19. Mitophagy Modulators 20. Telomerase Activators SECTION III. Phytochemicals 21. Resveratrol 22. Curcumin 23. Quercetin 24. Genistein 25. Epigallocatechin Gallate 26. Berberine 27. Nanodelivery of phytobioactive compounds: a promise in anti-aging medicine SECTION IV. Outcomes and Concluding Thoughts 28. Ethical perspectives on advances in biogerontology 29. Implications for Public Health Policy 30. The Business of Anti-Aging Science

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Author Information

Dr. Vaiserman is head of the Laboratory of Epigenetics at the Institute of Gerontology, where his research has focused on long-term health consequences of adverse conditions in early life, genetic and epigenetic mechanisms of age-associated diseases, telomere length in patients with age-related chronic diseases, and molecular mechanisms mediating lifespan in Drosophila. He earned his PhD from the Institute of Gerontology, Kiev, Ukraine in 2004. During the last 7 years, Dr. Vaiserman was Project Leader for several Ukrainian government sponsored research projects. Dr. Vaiserman is also a member of the editorial boards of the journals Biogerontology, Frontiers in Genetics of Aging, and Gerontology & Geriatric Research. To-date, he has published four book chapters, as well as 65 papers in peer reviewed journals.

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