Overview

The Annexins is focused on a specific family of calcium and membrane-binding proteins, annexins, ubiquitously spread within living organisms, including animals, plants and fungi. The volume covers important areas of annexinology. The characterization of structural-functional relationship within the annexin family of proteins, together with emerging transgenic animal models, provides an up-to-date overview of potential physiological roles of annexins. Growing evidence of participation of annexins in human diseases, called annexinopathies, related to disturbances in signal transduction, vesicular traffic, ion homeostasis and energy metabolism within the cell. The book will attract a broad scientific audience, not only scientists interested in annexins, but also others involved in multidisciplinary studies, as well as undergraduate and postgraduate students. It can be used in courses relating to special topics such as calcium homeostasis, calcium-binding proteins, membrane structure and transport properties, various signal transduction pathways, and membrane trafficking.

Full Product Details

Author:   Joanna Bandorowicz-Pikula
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of the original 1st ed. 2003
Dimensions:   Width: 15.60cm , Height: 1.50cm , Length: 23.40cm
Weight:   0.450kg
ISBN:  

9781461348412

ISBN 10:   1461348412
Pages:   273
Publication Date:   23 October 2012
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Preface; J. Bandorowicz-Pikula. Structure, function and evolution of the annexin gene superfamily; M.P. Fernandez, R.O. Morgan. Structural conservation and functional versatility: allostery as a common annexin feature; A. Hofmann, R. Huber. Self-assembly of Annexin A5 on lipid membranes; N. Govorukhina, W. Bergsma-Schutter, C. Mazères-Dubut, S. Mazères, E. Drakopoulou, L. Bystrykh, F. Oling, A. Mukhopadhyay, I. Reviakine, J. Lai Kee Him, A. Brisson. Annexin gene knock-out models; A. Tomas, M.J. Hayes, D. Roy, B. Young, S.E. Moss. Annexin V: stimulation-dependent association with membrane protein; E. Tzima, J.H. Walker. Annexin 1 crystal structure interaction of annexins with membranes; A. Rosengarth, H. Luecke. Annexin II heterotetramer analysis of a pleiotropic protein; N.R. Filipenko, D.M. Waisman. Role of annexin VI in receptor-mediated endocytosis, membrane trafficking and signal transduction; T. Grewal, C. Enrich, S. Jackle. Annexins and tissue mineralization matrix vesicles, ion channel activity of annexins and annexin V/collagen interactions; T. Kirsch. Acidic pH-induced ion channels formed by annexin VI transformation from soluble to membrane integral protein; S. Pikula. Annexinopathy in the antiphospholipid syndrome; J.H. Rand, Xiao-Xuan Wu. Annexins and phospholipases; A.G. Buckland, D.C. Wilton. Role of annexin II tetramer in the regulation of plasmin activity; Kyu-Sil Choi, D.K. Fogg, S. Fitzpatrick, D.M. Waisman. The nucleotide face of annexins; J. Bandorowicz-Pikula. Involvement of human annexins in viral entry; E. Depla.

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