Overview

Interest in the humane and scientifically justifiable use of research animals has intensified since the publication of the 2nd edition of Animal Models in Cardiovascular Research. This completely revised and updated edition will provide information essential to any researcher interested in using animal models for cardiovascular research, or any research which requires normal cardiovascular function. The format and presentation will be changed to make the text more easy to read and use: (1) This edition is in outline format, for ease and utility. (2) The opening chapter includes more information on the cardiovascular effects of post-operative analgesia and will address the recognition of pain behavior in species commonly used in research settings, particularly rats and mice. (3) New edition includes reference material more useful to researchers using transgenic and naturally occurring animal models to dissect these mechanisms.

Full Product Details

Author:   David Gross
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   3rd ed. 2009
Dimensions:   Width: 15.50cm , Height: 2.50cm , Length: 23.50cm
Weight:   1.810kg
ISBN:  

9780387959610

ISBN 10:   0387959610
Pages:   431
Publication Date:   09 June 2009
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

General Principles of Animal Selection and Normal Physiological Values.- Preanesthesia, Anesthesia, Chemical Restraint, and the Recognition and Treatment of Pain and Distress.- Normal Cardiac Function Parameters.- Measuring Cardiac Function.- Measuring Vascular Function and Ventricular/Arterial Coupling Dynamics.- Isolated Heart Preparations, Problems, and Pitfalls.- Cardiovascular Effects of Anesthetics, Sedatives, Postoperative Analgesic Agents, and Other Pharmaceuticals.- Naturally Occurring and Iatrogenic Animal Models of Valvular, Infectious, and Arrhythmic Cardiovascular Disease.- Iatrogenic Models of Ischemic Heart Disease.- Iatrogenic, Transgenic, and Naturally Occurring Models of Cardiomyopathy and Heart Failure.- Iatrogenic, Congenic, and Transgenic Models of Hypertension.- Naturally Occurring, Iatrogenic and Transgenic Models of Atherosclerotic Disease.- Animal Models for the Study of Neurohumeral and Central Neural Control of the Cardiovascular System.- Other Transgenic Animal Models Used in Cardiovascular Studies.

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Author Information

Dr. David R. Gross entered private veterinary practice after earning the DVM degree from Colorado State University in 1960. In 1974 he was awarded the PhD degree in physiology from the Ohio State University beginning a 36-year career in academics that culminated as professor and head of the Department of Veterinary Biosciences in the College of Veterinary Medicine, University of Illinois, Urbana-Champaign. Dr. Gross’ research career encompassed 58 funded projects totaling over $5.5 million and 91 papers published in refereed journals using a wide variety of animal models. Ironically his three most-cited research papers received no external funding. He and his colleagues showed that feeding dietary cholesterol to rabbits induced Alzheimer’s-like lesions in the brain. Their work also showed that surgery involving cardiopulmonary bypass resulted in Alzheimer’s-like brain lesions in pigs. With another group of colleagues he helped pioneer minimally invasive coronary artery bypass grafting techniques using the pig as a model.

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