Overview

Animal experimentation has been one of the most controversial areas of animal use, mainly due to the intentional harms inflicted upon animals for the sake of hoped-for benefits in humans. Despite this rationale for continued animal experimentation, shortcomings of this practice have become increasingly more apparent and well-documented. However, these limitations are not yet widely known or appreciated, and there is a danger that they may simply be ignored. The 51 experts who have contributed to Animal Experimentation: Working Towards a Paradigm Change critically review current animal use in science, present new and innovative non-animal approaches to address urgent scientific questions, and offer a roadmap towards an animal-free world of science.

Full Product Details

Author:   Kathrin Herrmann ,  Kimberley Jayne
Publisher:   Brill
Imprint:   Brill
Volume:   22
Weight:   1.287kg
ISBN:  

9789004356184

ISBN 10:   9004356185
Pages:   714
Publication Date:   04 April 2019
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In stock  
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Table of Contents

Foreword  Peter Singer Preface  Kathrin Herrmann and Kimberley Jayne Acknowledgement Notes on Contributors Introduction  Kathrin Herrmann and Kimberley Jayne Part 1: Why and How to Shift the Paradigm 1 Refinement on the Way Towards Replacement: Are We Doing What We Can?  Kathrin Herrmann 2 How to Evaluate the Science of Non-human Animal Use in Biomedical Research and Testing: A Proposed Format for Debate  Ray Greek and Lisa A. Kramer 3 How Can the Final Goal of Completely Replacing Animal Procedures Successfully be Achieved?  Christiane Baumgartl-Simons and Christiane Hohensee 4 Disease Prevention with a Plant-based Lifestyle  Sabina Vyas Part 2: Politics and Legislation of Animal Experimentation 5 Political Campaigning: Where Scientific and Ethical Arguments Meet Public Policy  Emily McIvor 6 Rethinking the 3Rs: From Whitewashing to Rights  Charlotte E. Blattner 7 Contesting Animal Experiments through Ethics and Epistemology: In Defense of a Political Critique of Animal Experimentation  Arianna Ferrari Part 3: Openness in Animal Experimentation 8 The Moral Status of Animal Research Subjects in Industry: A Stakeholder Analysis  Sarah Kenehan 9 Increasing the Transparency of Animal Experimentation: An Australian Perspective  Monika Merkes and Rob Buttrose 10 Wasted Money in United States Biomedical and Agricultural Animal Research  Jim Keen Part 4: The Ethics and Philosophy of Animal Experimentation 11 Ethics, Efficacy, and Decision-making in Animal Research  Lawrence A. Hansen and Kori Ann Kosberg 12 Beyond Plausibility Checks: A Case for Moral Doubt in Review Processes of Animal Experimentation  Mara-Daria Cojocaru and Philipp von Gall 13 Human Wrongs in Animal Research: A Focus on Moral Injury and Reification  Jane Johnson and Anna Smajdor Part 5: Effectiveness of the Animal Model 14 Critically Evaluating Animal Research  Andrew Knight 15 Extrapolation of Animal Research Data to Humans: An Analysis of the Evidence  Rebecca Ram 16 Is Animal-based Biomedical Research being Used in Its Original Context?  Constança Carvalho, Daniel Alves, Andrew Knight and Luis Vicente 17 The Scientific Problems with Using Non-human Animals to Predict Human Response to Drugs and Disease  Ray Greek and Lisa A. Kramer 18 Replacing Animal Tests to Improve Safety for Humans  Kathy Archibald, Robert Coleman and Tamara Drake 19 Genetic Modification of Animals: Scientific and Ethical Issues  Jarrod Bailey 20 Animal Research for Alzheimer Disease: Failures of Science and Ethics  John J. Pippin, Sarah E. Cavanaugh and Francesca Pistollato 21 Behavioral Research on Captive Animals: Scientific and Ethical Concerns  Kimberley Jayne and Adam See Part 6: Animal-free Education and Training 22 Modernizing Biomedical Training: Replacing Live Animal Laboratories with Human Simulation  John Pawlowski, David Feinstein, Marie L. Crandall and Shalin Gala 23 Humane Education: The Tool for Scientific Revolution in Brazil  Vanessa Carli Bones, Rita de Cassia Maria Garcia, Gutemberg Gomes Alves, Rita Leal Paixão, Alexandro Aluísio Rocha, Karynn Capilé and Róber Bachinski Part 7: The Paradigm Shift: Advanced Animal-free Approaches 24 Recent Developments in Alternatives to Animal Testing  Katy Taylor 25 The Changing Paradigm in Preclinical Toxicology: in vitro and in silico Methods in Liver Toxicity Evaluations  Fozia Noor 26 The Potential of Organ on Chip Technology for Replacing Animal Testing  Malcolm Wilkinson 27 When is an Alternative Not an Alternative? Supporting Progress for Absolute Replacement of Animals in Science  Craig Redmond 28 Research and Testing Without Animals: Where are We Now and Where are We Heading?  Thomas Hartung  Afterword: Evidence Over Interests  John P. Gluck  Index

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Author Information

Kathrin Herrmann is a veterinarian and expert for animal welfare science, ethics and law with focus on the 3Rs of animal experimentation. She currently works for the Center for Alternatives to Animal Testing (CAAT) at Johns Hopkins University, MD, USA. Kimberley Jayne, PhD, has over a decade of research and educator experience working to enhance the welfare of animals in laboratory and entertainment environments. She now works in animal protection, using her experience to end the use of animals in these industries.

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