Overview

A fast moving research area where there is an ever-expanding interest, and which impacts upon a wide variety of genetic diseases. Important introductory section which considers the merits of methods employed in these studies, and examines factors which influence study design. Looks at the different approaches that have been taken to study complex inherited diseases by considering a variety of common diseases as models. Discusses the successes achieved through past studies, with implications for future research.Multifactorial or complex diseases are those characterized by increased risks within families, caused by more than one gene, and which predominantly have a tremendous impact on morbidity and mortality in the general public. Examples of multifactorial diseases include: common cancers - breast, bowel, ovary etc.: Alzheimer's; epilepsy; diabetes; multiple sclerosis; schizophrenia and manic depression; asthma; rheumatoid arthritis etc.

Full Product Details

Author:   Timothy Bishop (ICRF Genetic Epidemiology Laboratory, St. James's Hospital, Leeds, U.K.) ,  P. Sham (Institute of Psychiatry, King's College London, Denmark Hill, London, U.K.)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Dimensions:   Width: 15.20cm , Height: 2.00cm , Length: 22.90cm
Weight:   0.830kg
ISBN:  

9780121016104

ISBN 10:   0121016102
Pages:   320
Publication Date:   03 March 2009
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Paperback
Publisher's Status:   Out of Print
Availability:   In Print  
Limited stock is available. It will be ordered for you and shipped pending supplier's limited stock.

Table of Contents

Contributors. Abbreviations. Preface. Foreword. Principles of Molecular Genetics, G. Taylor. Methods for Mapping Complex Disease Traits, G.M. Lathrop. The Design of Studies for Investigating Linkage and Association, J.P. Rice, N.L. Saccone and B.K. Suarez. Genetic Susceptibility to Common Cancers: A Model for Genetics of a Complex Trait, D.E. Goldgar. Genetic Epidemiology of Alzheimer's Disease, G. Roks and C.M. van Duijn. Molecular Genetic Studies of the Idiopathic Epilepsies, A. Makoff, L. Nashef and P. Asherson. Type 2 Diabetes Mellitus and Maturity-onset Diabetes of the Young, R.L. Hanson and W.C. Knowler. Type 1 Diabetes, L.L. Field. Bipolar Disorder, N. Craddock and I. Jones. Schizophrenia, M.J. Owen, N.M. Williams and M.C. O'Donovan. Atopsy and Asthma, L.J. Palmer and W.O.C.M. Cookson. Rheumatoid Arthritis, J.H. Barrett and S. John. Genes and Environment in Eating Disorders and Obesity, D.A. Collier and J. Treasure. Depression and Anxiety, J. Moore, G.S. Malhi and P. McGuffin. Genetic Strategies for Common Complex Disorders: Ischemic Heart Disease as an Example, S.E. Humphries. Overview, P. Sham and T. Bishop. Index.

Reviews

Author Information

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions