Overview

This title provides updated knowledge on the basic features and mechanisms of cellular ageing. Contributions consider genetic and environmental factors, failure of genetic and cellular repair mechanisms, and the epigenetic modifications that determine the final lifespan of cells. The book also provides an understanding on how aging mechanisms in mice, a most frequently used model, differ with that of humans who receive better tumour surveillance because of stringent controls on ageing mechanisms. It also appraises the use of modern technology for ageing studies and its intervention. This book serves as an excellent reading on cellular ageing for undergraduate students, researchers and experts of this area.

Full Product Details

Author:   S. Kaul ,  Renu Wadwha
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   2003 ed.
Volume:   2
Dimensions:   Width: 16.00cm , Height: 1.70cm , Length: 24.00cm
Weight:   0.584kg
ISBN:  

9781402013751

ISBN 10:   1402013752
Pages:   276
Publication Date:   31 October 2003
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of print, replaced by POD  
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Table of Contents

1. Aging outside the body: usefulness of the Hayflick system.- 2. Genetics of cellular aging.- 3. Aging of fibroblasts.- 4. Aging of endothelial cells.- 5. In vitro senescence of human osteoblasts.- 6. T cell immunosenescence.- 7. Aging of premature-aging syndrome cells.- 8. The p53 pathway, cancer and aging.- 9. Regulation of cellular senescence by the retinoblastoma pathway.- 10. Telomeres and cellular aging.- 11. Molecular chaperones and cellular aging.- 12. Cellular senescence pathways in mouse and human.- 13. Therapeutic induction of cellular senescence: nuclear matrix in senescence.- 14. Use of hammerhead ribozymes foraging and cancer.

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