Overview

The major scientific advancements in the study of nutrition and cancer in the last six years derive from the extensive use of molecular approaches to perform research in the nutritional field. Moreover, the fundamental observation of R. Doll and R. Peto (1981), which suggested that at least 35% of all cancers (with large differences among different tumors) might be prevented by dietary regimens, has been definitively confirmed by epidemiological studies. The molecular studies reported in this volume include all of the major aspects of investigation on human nutrition and malignant transformation. In the last decade a large number of compounds responsible for the biological activity of human foods has been identified and characterized. These molecules not only include important and well-known risk factors but, most promising, compounds, which might exert chemopreventive activity. Among them, antioxidants (such as vitamins, phenols, and lycopene) seem to play a critical role in reducing the risk of cancer at different anatomical sites, including colon, breast, and prostate malignancies. Other molecules, derived from fiber bacterial intestinal degradation (short fatty acids), are of interest, even if their importance has not been completely unraveled and is still the subject of debate.

Full Product Details

Author:   Vincenzo Zappia ,  Fulvio della Ragione ,  Alfonso Barbarisi ,  Gian Luigi Russo
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of hardcover 1st ed. 2000
Volume:   472
Dimensions:   Width: 17.80cm , Height: 1.70cm , Length: 25.40cm
Weight:   1.270kg
ISBN:  

9781441933317

ISBN 10:   144193331
Pages:   313
Publication Date:   06 December 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Epidemiological Studies: Risk Factors and Diets.- 1. Diet and Cancer: Perspectives of Prevention.- 2. EPIC-Italy: A Molecular Epidemiology Project on Diet and Cancer.- 3. Nutritional Factors in Human Cancers.- 4. Alcohol and Cancer.- 5. Energy Sources and Risk of Cancer of the Breast and Colon-Rectum in Italy.- 6. Organochlorines and Breast Cancer: A Study on Neapolitan Women.- 7. Olive Oil Consumption and Cancer Mortality in Italy: A Correlation Study.- Cell Growth and Differentiation: Molecular Bases of Nutrient Effects.- 8. Cell Division Cycle Alterations and Human Tumors.- 9. Regulation of p53 Function in Normal and Malignant Cells.- 10. The Role of Micronutrients in DNA Synthesis and Maintenance.- 11. Biological Effects of Hydroxytyrosol, A Polyphenol from Olive Oil Endowed with Antioxidant Activity.- 12. Protective Effects of Butyric Acid in Colon Cancer.- 13. Short-Chain Fatty Acid in the Human Colon: Relation to Inflammatory Bowel Diseases and Colon Cancer.- 14. Brassica Vegetables and Cancer Prevention: Epidemiology and Mechanisms.- 15. Stilbenes and Bibenzyls with Potential Anticancer or Chemopreventive Activity.- 16. Post-Translational Modifications of Eukaryotic Initiation Factor-5A (eIF-5A) as a New Target for Anti-Cancer Therapy.- Molecular Epidemiology: An Innovative Trend in Cancer Prevention.- 17. Diet, Fibers, and Colon Cancer.- 18. Phytochemicals as Modulators of Cancer Risk.- 19. Low Dose Exposure to Carcinogens and Metabolic Gene Polymorphisms.- 20. Carcinogen-DNA Adducts as Tools in Risk Assessment.- 21. Significance of Genetic Polymorphisms in Cancer Susceptibility.- 22. DNA Repair Pathways and Cancer Prevention.- Nutritional Intervention for Cancer Prevention and Perspectives.- 23. Cereals, Fiber, and Cancer Prevention.- 24. Carnitine System andTumor.- Contributors.

Reviews

'...most are well referenced. As such, they may provide the non-specialist reader with an update and an entry point to the wider literature. ... the book would be a valuable addition to libaries but...' Advances in nutrition and cancer 2 (2001)

'...most are well referenced. As such, they may provide the non-specialist reader with an update and an entry point to the wider literature. ... the book would be a valuable addition to libaries but...' Advances in nutrition and cancer 2 (2001)

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