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OverviewThis volume presents a collection of invited papers from the First European Workshop on Molecular Toxicology, held in Sophia Antipolis, France. It covers eight selected topics in molecular toxicology. The first two are devoted to physics , dealing respectively with advanced instrumentation enabling location and quantification of xenobiotics in cells and organs, and computer-assisted assessment of risk (QSAR). A comprehensive and up-to-date survey of molecular toxicology in the pharmaceutical industry is included. The third section addresses the effect of xenobiotics on cell-cycle actors. Sections 4-6 deal with molecular toxicology in skin, kidney, nerve, liver and pancreatic cells. The last two sections describe methods to probe DNA damage and repair, and immunotoxicity. Full Product DetailsAuthor: Claude Reiss , Simone Parvez , Labbe , Hasan ParvezPublisher: Brill Imprint: VSP International Science Publishers ISBN: 9789067642781ISBN 10: 9067642789 Pages: 568 Publication Date: 01 February 1998 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Out of stock  The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available. Table of ContentsCellular and intracellular monitoring of xenobiotics - new physical methods and general strategies: molecular cartographies in cells and tissues by secondary ion mass spectrometry, P. Galle; the use of video microscopy and confocal laser scan microscopy to study the mechanisms of cytotoxicity in vitro in individual living cells, J.F. Nagelkerke, H.J.G.M. De Bont; ultrasensitive in situ terminal nick end labelling using confocal laser scanning microscopy, - a methodological approach, H. Bruzzoni Giovanelli et al; quantitative analysis of apoptotic neuronal cell death by single cell gel electrophoresis assay, W. Maruyama, M. Naoi; high performance capillary electrophoresis (HPCE) in molecular toxic assessment and oxidative stress - comparison with HPLC/coulometric array detection, H. Parvez et al; routine staining for the diagnosis of neuro muscular diseases -traditional methods and kits, s. Daniel, M. Mora; interactions between a cell biology unit and a cell bank for environmental toxicology monitoring - example of the European collection of cell cultures and the setting up of a cellular assay for water toxin deduction, T. Battle, J.K. Phillips; molecular toxicology in the pharmaceutical industry, G. Labbe. Quantitative xenobiotic structure-biological activity relationship (QSAR): quantitative structure-activity relationships in toxicology - from fundamentals to applications, V.K. Gombar; QSTR applications in acute, chronic, and developmental toxicity, and carcinogenicity, K. Enslein. Cell cycle toxicants: assessment of xenobiotic effects on the cell cycle, C. Reiss et al; chemical carcinogenesis as a consequence of cell cycle dysregulation, J.A. Rininger et al; involvement of nuclear receptors in toxicology -role of peroxisome proliferator-activated receptors (PPARs), N. Latruffe et al; potential of parental and transfected human cell lines for assessing toxicological effects of xenobiotics, C. Delescluse et al. Skin toxicity: eicosanoids as endogenous mediators of carcinogenesis and reporters of skin toxicity - cancer chemoprevention by inhibitors of arachidonic acid metabolism, F. Marks et al; relationship between photomutagenicity and photocarcinogenicity, K.S. Loveday. Molecular toxicity in kidney and nerve cells: cell engineering of the human cysteine conjugate beta lyase gene and applications to nephrotoxicity, G.G. Gibson et al; differential cerebrospinal fluid levels of neurotransmitters in viral and bacterial meningitis, G.A. Qureshi et al. (Part contents).ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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