Overview

The second edition of Advances in Bioinformatics presents the latest developments in bioinformatics in gene discovery, genome analysis, genomics, transcriptomics, proteomics, metabolomics, metabolic flux analysis, drug discovery, and drug repurposing. It includes advancements in the applications of bioinformatics in the analysis of non-coding RNA, next-generation sequencing, genome-scale modelling, high throughput drug screening, precision medicine, automation and artificial intelligence, and machine learning. The chapter also summarizes the technologies and concepts that form the basis of this functional genomics approach. Additionally, the book highlights some of the areas in which bioinformatics resources and methods are being developed to support the drug discovery pipeline. The chapter also discusses the role of bioinformatics in modelling and simulations of molecular biology systems in pathways identification and design. It is a valuable source of information for beginners in bioinformatics and students, researchers, scientists, clinicians, practitioners, policymakers, and stakeholders who are interested in harnessing the potential of bioinformatics in biomedical and allied sciences.

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Dr. Vijai Singh is an associate professor and head of the Department of Biosciences, School of Science at Indrashil University, Rajpur, Mehsana, Gujarat, India. He was an assistant professor in the Department of Biological Sciences and Biotechnology at the Institute of Advanced Research, Gandhinagar, India and an assistant professor in the Department of Biotechnology at the Invertis University, Bareilly, India. Prior to that, he was a Postdoctoral Fellow in the Synthetic Biology Group at the Institute of Systems and Synthetic Biology, Paris, France and the School of Energy & Chemical Engineering at the Ulsan National Institute of Science and Technology, Ulsan, South Korea. He received his Ph.D. in Biotechnology (2009) from the National Bureau of Fish Genetic Resources, Uttar Pradesh Technical University, Lucknow, India with a research focus on the development of molecular and immunoassays for diagnosis of Aeromonas hydrophila. His research interests are focused on building novel biosynthetic pathways for the production of medically and industrially important biomolecules. Additionally, his laboratory is working on CRISPR-Cas9 tools for genome editing. He has more than 8 years of research and teaching experience in synthetic biology, metabolic engineering, bioinformatics, microbiology, and industrial microbiology.. Dr. Ajay Kumar as a professor and head of the Department of Biotechnology at the Faculty of Engineering and Technology at Rama University Uttar Pradesh, Kanpur, Dr. Kumar has successfully served more than 20 years in research and teaching. He has experience in genomics & proteomics, bioprocess engineering, bioinformatics, microbiology, industrial microbiology, genetic engineering, fermentation technology, and food biotechnology. He has held several key positions in well-renowned Universities and Engineering Institutes. Dr. Kumar received his M. Tech. (Biotechnology) from the Institute of Engineering & Technology, Lucknow, India and Ph.D. from the ICAR-Central Institute for Research on Goats, Mathura, India. His expertise lies in computational vaccine & drug development, cancer biology genomics & proteomics, and fermentation He is also a member of the Board of Study and Academic Council of Rama University Kanpur and Regional Food Research Analysis Center, Department of horticulture & food processing, Lucknow, Uttar Pradesh. Being a member of a professional body such as the international association of engineers (IAENG) and INSA, he has rendered consultancy services in vaccine research.

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