Overview

Upon completion of the human genome project over 800 G protein-coupled receptor 1 (GPCR) genes, subdivided into five categories, were identified. These receptors sense a diverse array of stimuli, including peptides, ions, lipid analogues, light and odour, in a discriminating fashion. Subsequently, they transduce a signal from the ligand–receptor complex into numerous cellular responses. The importance of GPCRs is further reflected in the fact that they constitute the most common target for therapeutic drugs across a 2 wide range of human disorders. Phylogenetic analysis of GPCRs produced the GRAFS classification system, which subdivides GPCRs into five discrete families: glutamate, rhodopsin, adhesion, frizzled/taste2 and secretin receptors. The adhesion-GPCR family 2 can be further subdivided into eight groups. The field of adhesion-GPCR biology has indeed become large enough to require a volume dedicated solely to this field. The contributors to this book have made a courageous effort to address the key concepts of adhesion-GPCR biology, including the evolution and biochemistry of adhesion-GPCRs; there are extensive discussions on the functional nature of these receptors during development, the immune response and tumourgenesis. Finally, there are chapters dedicated to adhesion-GPCR signalling, an area of intense investigation.

Full Product Details

Author:   Simon Yona ,  Martin Stacey
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   2010 ed.
Volume:   706
Dimensions:   Width: 17.80cm , Height: 1.40cm , Length: 25.40cm
Weight:   0.623kg
ISBN:  

9781441979124

ISBN 10:   1441979123
Pages:   199
Publication Date:   11 January 2011
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us.

Table of Contents

The Adhesion GPCRs; Gene Repertoire, Phylogeny and Evolution.- 7TM-Cadherins: Developmental Roles and Future Challenges.- Latrophilin Signalling in Tissue Polarity and Morphogenesis.- GPS Proteolytic Cleavage of Adhesion-GPCRs.- The Latrophilins, “Split-Personality” Receptors.- Studies on the Very Large G Protein-Coupled Receptor: From Initial Discovery to Determining its Role in Sensorineural Deafness in Higher Animals.- Adhesion-GPCRs in the CNS.- GPR56 Interacts with Extracellular Matrix and Regulates Cancer Progression.- Adhesion-GPCRs in Tumorigenesis.- Immunity and Adhesion-GPCRs.- CD97 in Leukocyte Trafficking.- The Role of CD97 in Regulating Adaptive T-Cell Responses.- F4/80: The Macrophage-Specific Adhesion-GPCR and its Role in Immunoregulation.- Signal Transduction Mediated through Adhesion-GPCRs.- Emerging Roles of Brain-Specific Angiogenesis Inhibitor 1.- Adhesion-GPCRs in the Male Reproductive Tract.

Reviews

Author Information

Simon Yona, PhD, graduated from Kings College, University London with a BSc in Physiology and a MSc in Pharmacology, before completing a PhD with Prof. R.J. Flower FRS and Prof. M. Perretti, at St. Bartholomew's Hospital, University of London. Following his doctorate Simon took up a Postdoctoral Research position with Prof. S. Gordon FRS, at the Sir William Dunn School of Pathology, University of Oxford, where he investigated the roles and functions of the leukocyte restricted adhesiona'GPCRs. Dr. Yona moved from Oxford to join the group of Prof. S. Jung, at the Weizmann Institute of Science, Rehovot, when he was awarded a Federation of European Biochemical Societies, International Fellowship. Currently he is investigating the developmental profile of mononuclear phagocytes in a number of pathologies. Martin Stacey, DPhil (Oxon), graduated from Hertford College, University of Oxford with an MBiochem before completing a DPhil in the laboratory of Prof. S. Gordon FRS. He continued working at the Sir William Dunn School of Pathology for a number of years where he cloned and characterized leukocyte adhesiona'GPCRs and demonstrated the existence of their cell surface ligands. More recently, Dr. Stacey has been appointed as a Lecturer of Immunology, at the University of Leeds where his laboratory focuses on adhesiona'GPCRs and role of myeloid cells in human disease.

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions