Overview

Distributional data, population studies and in vitro investigations indicate that glucose-6-phosphate dehyrodgenase (G6PD) deficiency is associated with human population adaptation to falciparum malaria. This volume discusses the biochemical mechanisms underlying this genetically based protection, providing coverage of how dietary factors and traditional medicines interact with G6PD locus to maximize antimalarial adaptation in human populations. The book also presents data which demonstrates the relative protection of G6PD deficient genotypes against severe falciparum malaria and reviews the epidemiology of favism, neonatal jaundice, and other negative consequences of the G6PD deficient condition. A final focus is on the micromapping of G6PD deficient allele frequencies in Sardinia and southern Italy and its relationship to past malarial history as an extension and re-evaluation of the classical studies carried out in this area.

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9789057005046

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