Overview

Based upon the latest developments in the field of medicinal chemistry, detailed synthesis mechanism of drugs and their mode of action inside the body, this book treats many aspects of organic medicinal compounds; their discovery, action, and development into clinical agents. All the principles discussed in the book are based on fundamental organic chemistry, physical chemistry and biochemistry. Medicinal chemistry plays a key role in pharmaceutical research and new drug discovery; the structural modification may help in increasing the potency of desired active and/or to decrease the intensity of adverse effects. This book presents a review of basic principles of medicinal chemistry and to explain the effects of structural modification of the lead nucleus on the selectivity of action, duration of action and frequency of adverse effect. An effort has been made to stress upon basic pharmacology in detail wherever needed.

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