Overview

Most traits in nature and of importance to agriculture are quantitatively inherited. These traits are di?cult to study due to the complex nature of their inheritance. However, recent developments of genomic technologies provide a revolutionary means for unraveling the secrets of genetic variation in quantitative traits. Genomic te- nologies allow the molecular characterization of polymorphic markers throughout the entire genome that are then used to identify and map the genes or quantitative trait loci (QTLs) underlying a quantitative trait based on linkage analysis. Statistical analysis is a crucial tool for analyzing genome data, which are now becoming increasingly available for a variety of species, and for giving precise exp- nations regarding genetic variation in quantitative traits occurring among species, populations, families, and individuals. In 1989, Lander and Botstein published a ha- mark methodological paper for interval mapping that enables geneticists to detect and estimate individual QTL that control the phenotype of a trait. Today, interval mappingisanimportantstatisticaltoolforstudyingthegeneticsofquantitativetraits at the molecular level, and has led to the discovery of thousands of QTLs responsible for a variety of traits in plants, animals, and humans. In a recent study published in Science, Li, Zhou, and Sang (2006, 311, 1936–1939) were able to characterize the molecular basis of the reduction of grain shattering – a fundamental selection process for rice domestication – at the detected QTL by interval mapping.

Full Product Details

Author:   Rongling Wu ,  Changxing Ma ,  George Casella
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of hardcover 1st ed. 2007
Dimensions:   Width: 15.50cm , Height: 2.00cm , Length: 23.50cm
Weight:   0.587kg
ISBN:  

9781441919120

ISBN 10:   1441919120
Pages:   368
Publication Date:   24 November 2010
Audience:   Professional and scholarly ,  Professional and scholarly ,  Professional & Vocational ,  Postgraduate, Research & Scholarly
Format:   Paperback
Publisher's Status:   Active
Availability:   Out of print, replaced by POD  
We will order this item for you from a manufatured on demand supplier.

Table of Contents

Basic Genetics.- Basic Statistics.- Linkage Analysis and Map Construction.- A General Model for Linkage Analysis in Controlled Crosses.- Linkage Analysis with Recombinant Inbred Lines.- Linkage Analysis for Distorted and Misclassified Markers.- Special Considerations in Linkage Analysis.- Marker Analysis of Phenotypes.- The Structure of QTL Mapping.- Interval Mapping with Regression Analysis.- Interval Mapping by Maximum Likelihood Approach.- Threshold and Precision Analysis.- Composite QTL Mapping.- QTL Mapping in Outbred Pedigrees.

Reviews

From the Reviews: [I]t is a big help and guidance in the field of statistical developments for genetic mapping, synthesised all in one volume helping to build a bridge between genetics and statistics. (Lutz Bunger, Genetic Research, 89, 2007) ...[T]his is an ideal book for a young researcher looking for an exciting and developing field to get into. (International Statistics Review, April 2008)

From the Reviews: [I]t is a big help and guidance in the field of statistical developments for genetic mapping, synthesised all in one volume helping to build a bridge between genetics and statistics. (Lutz Bunger, Genetic Research, 89, 2007) ...[T]his is an ideal book for a young researcher looking for an exciting and developing field to get into. (International Statistics Review, April 2008)

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