Molecular Targeting and Signal Transduction

Author:   Rakesh Kumar
Publisher:   Springer-Verlag New York Inc.
Edition:   2004 ed.
Volume:   119
ISBN:  

9781402078224


Pages:   331
Publication Date:   30 April 2004
Format:   Hardback
Availability:   In Print   Availability explained
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Molecular Targeting and Signal Transduction


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Overview

"Our limited understanding of cellular regulatory signal-transduction-networks has been a barrier to progress in improving the overall cure-rate of human cancers. Delineation of the physiologic roles of the specific regulatory signaling components, with known association with metastatic phenotypes, is a highly promising area which will likely provide the next generation of targeted strategies in the future of molecular cancer medicine. These signaling components are likely to be used in diagnosis, prognosis, and as novel targets for therapeutic development. This book brings together up-to-date summaries by leading cancer researchers on the major principles of cancer cell biology: survival, apoptosis, adhesion, and cell cycle deregulation. It is directed at clinicians and scientists working in the areas of experimental and molecular therapeutics, molecular medicine, translational cancer research, and bio-medical sciences in general. ""Modern cancer therapy targets critical signalling molecules responsible for cell proliferation. This text describes the key pathways and factors involved in this process. Distinguished leaders in the field discuss the therapeutic compounds and strategies being developed for the treatment of malignant disease."" - Steven T. Rosen, M.D., Series Editor"

Full Product Details

Author:   Rakesh Kumar
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   2004 ed.
Volume:   119
Dimensions:   Width: 15.50cm , Height: 2.00cm , Length: 23.50cm
Weight:   0.710kg
ISBN:  

9781402078224


ISBN 10:   1402078226
Pages:   331
Publication Date:   30 April 2004
Audience:   General/trade ,  College/higher education ,  Professional and scholarly ,  General ,  Tertiary & Higher Education
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print   Availability explained
This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us.

Table of Contents

Biology of the Epidermal Growth Factor Receptor Family.- Integrin Signaling in Cancer.- Regulators of Vascular Endothelial Growth Factor Expression in Cancer.- Integrin-Linked Kinase (ILK) in Combination Molecular Targeting.- P21-Activated Kinase 1: An Emerging Therapeutic Target.- Basis and Importance of SRC as a Target in Cancer.- Therapeutic Targeting of the Receptor Tyrosine Kinase Met.- Nuclear Factor-?B Activation Mediates Cellular Transformation, Proliferation, Invasion Angiogenesis and Metastasis of Cancer.- The P53 Pathway: Targets for the Development of Novel Cancer Therapeutics.- Runx Protein Signaling in Human Cancers.- Signal Transduction Mediated by Cyclin D1: from Mitogens to Cell Proliferation: A Molecular Target with Therapeutic Potential.- Signal Transduction Pathways in BCR-ABL Transformed Cells.- Estrogen Receptors and Anti-Estrogen Therapies.- Targeting Endothelin Axis in Cancer.- km23: A Novel TGF? Signaling Target Altered in Ovarian Cancer.

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