Overview

First published in 1990: Mechanisms of Differentiation, Volumes 1 and 2, is comprised of review chapters addressing various topics of current interest in this important area of research. Topics discussed include genes controlling differentiation, changes in gene expression during differentiation, induction of differentiation, induction of differentiation as a mode of action of chemotherapeutic agents, and the effect of cell shape, growth factors and differentiation modulating agents on the differentiated cell phenotype.

Full Product Details

Author:   Paul B. Fisher
Publisher:   Taylor & Francis Ltd
Imprint:   CRC Press
ISBN:  

9780367260590

ISBN 10:   036726059
Pages:   205
Publication Date:   12 January 2022
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Not yet available  
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Table of Contents

1. Modulation of Differentiation: Potential Mechanism by Which Interferons Induce Antitumor Activity 2. Regulation of Tumor Antigen Expression by Recombinant Interferons 3. Induction of Terminal Differentiation of Human Leukemic Cells by Chemotherapeutic and Cytotoxic Drugs 4. Induced Differentiation of Transformed Cells with Polar/Apolar Compounds and the Reversibility of the Transformed Phenotype 5-Azacytidine 6. Induction of Differentiation in Fibroblast Cells by Irradiation and Chemical Carcinogens 7. The Early Reactions and Factors Involved in In Vitro Erythroid Differentiation of Mouse Erythroleukemia (MEL) Cells 8. Regulation of Cell Contacts, Cell Configuration and Cytoskeletal Gene Expression in Differentiating Systems 9. Macrophage and Granulocyte Macrophage-Colony Stimulating Factor Effects on Human Monocyte Differentiation 10. Regulation of Phenotype by Transforming Growth Factor-b: Role of the Extracellular Matrix

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Author Information

Dr Paul B. Fisher, Ph.D. is Director of Neuro-Oncology Research and a Chernow Research Scientist in the Department of Neurosurgery, Pathology and Urology, Cancer Center/Institute of Cancer Rsearch, Columbia University, College of Physicians and Surgeons, New York, New York.

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