Overview

Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book. Key Features Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction. Includes summary of both causes and effects of these diseases. Discusses current and potential future therapies for mitochondrial dysfunction diseases Explores a wide variety of diseases caused by dysfunctional mitochondria.

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9781032178004

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Reviews

This book presents a compilation of the current knowledge associated with mitochondrial dysfunction. Although titled as a handbook, it represents a textbook that covers multiple aspects of the role of mitochondria in human disease. It is an extensive and detailed review of the biological importance of mitochondria. - Luis F Escobar, MD., MS., Peyton Manning Children's Hospital This book presents a compilation of the current knowledge associated with mitochondrial dysfunction. Although titled as a handbook, it represents a textbook that covers multiple aspects of the role of mitochondria in human disease. It is an extensive and detailed review of the biological importance of mitochondria. - Luis F Escobar, MD., MS., Peyton Manning Children's Hospital

"""This book presents a compilation of the current knowledge associated with mitochondrial dysfunction. Although titled as a handbook, it represents a textbook that covers multiple aspects of the role of mitochondria in human disease. It is an extensive and detailed review of the biological importance of mitochondria."" - Luis F Escobar, MD., MS., Peyton Manning Children's Hospital"

This book presents a compilation of the current knowledge associated with mitochondrial dysfunction. Although titled as a handbook, it represents a textbook that covers multiple aspects of the role of mitochondria in human disease. It is an extensive and detailed review of the biological importance of mitochondria. - Luis F Escobar, MD., MS., Peyton Manning Children's Hospital

Author Information

Shamim I. Ahmad earned his Master’s degree in Botany from Patna University, Bihar, India, and his PhD in Molecular Genetics from Leicester University, England. He then joined Nottingham Polytechnic as a grade 1 lecturer and subsequently was promoted to the post of Senior Lecturer. Ahmad now spends much of his time producing/writing medical books. For more than three decades he researched different areas of molecular biology/genetics including thymineless death in bacteria, genetic control of nucleotide catabolism, development of anti-AIDs drug, control of microbial infection of burns, phages of thermophilic bacteria, and microbial flora of Chernobyl after the nuclear power station accident. But his main interest is DNA damage and repair specifically by near-ultraviolet light mostly through the photolysis of biological compounds, production of reactive oxygen species, and their implications on human health including skin cancer. He also investigates near-ultraviolet photolysis of non-biological compounds such as 8-metoxypsoralen, mitomycin C, and their importance in psoriasis treatment and in Fanconi anemia. He has collaborated with the University of Osaka, Japan, and he and his colleagues were able to show that a number of naturally occurring enzymes were able to scavenge the reactive oxygen species. In 2003 he received a prestigious Asian Jewel Award in Britain for Excellence in Education. His long time ambition to produce medical books started in 2007 and since then he has published Molecular mechanisms of Fanconi Anemia, Molecular Mechanisms of Xeroderma Pigmentosum; Molecular Mechanisms of Cockayne Syndrome; Molecular Mechanisms of Ataxia Telangiectasia; Diseases of DNA repair; Neurodegenerative diseases; Diabetes: an Old Disease a New Insight, Obesity: a Practical Guide, Thyroid: Basic Science and Clinical Practice, and Ultraviolet light in Human Health, diseases and environment; also as a co-author the book on Diabetes: A comprehensive Treatise for patients and Caregivers. His most recent books are Reactive Oxygen Species in Biology and Human Health and Aging: Exploring a Complex Phenomenon.

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