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OverviewIn present work an attempt has been made to improve to the therapeutic efficacy, systemic absorption of drug and patient compliance by developing extended release matrix tablet formulations of diltiazem HCl (DIL) and verapamil HCL (VER). DIL and VER matrix tablet formulations were prepared by direct compression by using various combination of HPMC K15M CR and Eudragit RSPO polymer. A full factorial design was applied to systematically optimize drug release profile. For optimization study and data analysis software OPTI - STAT was developed. The optimized formulations shows regression value for Higuchi kinetics indicated the diffusion dependence for drug release. Stability trials up to three months displayed excellent reproducibility. In vivo studies were carried out on the optimized batches and CF using new developed HPLC and LC-MS/MS methods A good correlation between the dissolution profiles and bioavailability indicated a linear relationship between in vitro - in vivo data. Full Product DetailsAuthor: Dheeraj T Baviskar, Dr , Dr R B Sharma , D K Jain, Dr , Dr Dheeraj BaviskarPublisher: LAP Lambert Academic Publishing Imprint: LAP Lambert Academic Publishing Dimensions: Width: 15.20cm , Height: 1.90cm , Length: 22.90cm Weight: 0.476kg ISBN: 9783844392418ISBN 10: 3844392416 Pages: 324 Publication Date: 09 May 2011 Audience: General/trade , General Format: Paperback Publisher's Status: Active Availability: In stock  We have confirmation that this item is in stock with the supplier. It will be ordered in for you and dispatched immediately. Table of ContentsReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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