Overview

Delivering drugs in a water-insoluble formulation is a critical matter in therapeutic drug development. However, because a drug molecule has to be water soluble to be readily delivered to the cellular membrane while retaining its hydrophobic properties, issues surrounding water insolubility can postpone - or completely derail - important new drug development. Even much needed reformulation of currently marketed products can be significantly affected by these issues.This book systematically describes the techniques used for water-insoluble formulations, providing step-by-step guidance as well as scientific background on drug and water properties and how they contribute to solubilization and dissolution. A world-class team of experts discusses how these issues are viewed - and solved - by key industry and R&D institutions. This book provides a handy reference for pharmaceutical scientists in the handling of formulation issues related to water-insoluble drugs.; In addition, this book may be useful to pharmacy and chemistry undergraduate students, and pharmaceutical and biopharmaceutical graduate students, to enhance their knowledge in the techniques of drug solubilization and dissolution enhancement.

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9786611238681

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