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OverviewThe time seems ripe for a critical compendium of that segment of the biological universe we call viruses. Virology, as a science, having passed only recently through its descriptive phase of naming and numbering, has probably reached that stage at which relatively few new-truly new-viruses will be discovered. Triggered by the intellectual probes and techniques of molecular biology, genetics, bio chemical cytology, and high resolution microscopy and spectroscopy, the field has experienced a genuine information explosion. Few serious attempts have been made to chronicle these events. This comprehensive series, which will comprise some 6000 pages in a total of 19 volumes, represents a commitment by a large group of active investigators to analyze, digest, and expostulate on the great mass of data relating to viruses, much of which is now amorphous and disjointed, and scattered throughout a wide literature. In this way, we hope to place the entire field in perspective, and to develop an invaluable reference and sourcebook for researchers and students at all levels. This series is designed as a continuum that can be entered any where, but which also provides a logical progression of developing facts and integrated concepts. Full Product DetailsAuthor: Heinz Fraenkel-Conrat , Robert R. WagnerPublisher: Springer-Verlag New York Inc. Imprint: Springer-Verlag New York Inc. Edition: Softcover reprint of the original 1st ed. 1984 Volume: 19 Dimensions: Width: 17.80cm , Height: 2.90cm , Length: 25.40cm Weight: 1.053kg ISBN: 9781461357025ISBN 10: 1461357020 Pages: 556 Publication Date: 19 January 2012 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of Contents1 Cytopathic Effects of Viruses: A General Survey.- 1. Defining the Problem.- 2. Historical Background.- 3. Viral Cytopathology: General Principles.- 4. Specific Cytopathic Viruses: An Overview.- 5. Some Subcellular Targets of Pathogenic Viruses.- 6. Summary.- 7. References.- 2 Transcription by RNA Polymerase II.- 1. Introduction.- 2. Polymerase II Control Regions: In Vivo.- 3. Polymerase II Promoters: In Vitro.- 4. RNA Polymerase II and Factors.- 5. Closing Comments.- 6. References.- 3 Regulation of Eukaryotic Translation.- 1. Introduction.- 2. The Rate-Limiting Step in Translation.- 3. Functional Domains in Messenger RNA.- 4. Initiation of Translation.- 5. Role of Initiation Factors in Binding of mRNA.- 6. Translational Control by mRNA Competition.- 7. Translational Control by Regulation of eIF-2 Activity.- 8. Translational Regulation by Other Means.- 9. Parameters Determining Translational Efficiency of an mRNA Species.- 10. References.- 4 Picornavirus Inhibition of Host Cell Protein Synthesis.- 1. Introduction and Scope.- 2. Properties of Inhibition of Host Cell Protein Synthesis by Poliovirus.- 3. Proposed Models for Inhibition.- 4. Initiation Factors.- 5. Cap Recognition Activity.- 6. Polioviral Mediator of Host Cell Shut-off.- 7. Other Picornaviruses.- 8. Other Viruses That May Utilize Mechanisms Similar to Poliovirus.- 9. Concluding Remarks.- 10. References.- 5 Rhabdovirus Cytopathology: Effects on Cellular Macromolecular Synthesis.- 1. Introduction.- 2. Properties of Rhabdoviruses: A Brief Survey.- 3. Cellular Responses to Rhabdovirus Infection.- 4. Protein Synthesis Inhibition by Vesicular Stomatitis Virus.- 5. VSV Inhibition of Cellular Nucleic Acid Synthesis.- 6. Summary.- 7. References.- 6 Adenovirus Cytopathology.- 1. Introduction.- 2.Adenovirus—Mammalian Cell Interactions.- 3. Effects of Adenovirus Infection on Cellular DNA Metabolism.- 4. Cellular RNA Metabolism in Adenovirus-Infected Cells.- 5. Selective Translation of Viral mRNA in Productively-Infected Cells.- 6. Summary and Conclusions.- 7. References.- 7 The Effects of Herpesviruses on Cellular Macromolecular Synthesis.- 1. Introduction.- 2. Early Studies.- 3. Effects on DNA Synthesis.- 4. Effects on RNA Synthesis.- 5. Effects on Protein Synthesis.- 6. Other Herpesviruses.- 7. Mechanisms.- 8. Conclusion.- 9. References.- 8 Poxvirus Cytopathogenicity: Effects on Cellular Macromolecular Synthesis.- 1. Introduction.- 2. Poxvirus Cytopathogenicity.- 3. Concluding Remarks.- 4. References.- 9 Reovirus Cytopathology: Effects on Cellular Macromolecular Synthesis and the Cytoskeleton.- 1. Introduction.- 2. Reovirus Effects on Host Cell DNA Synthesis.- 3. Reovirus Effects on Host Cell RNA and Protein Synthesis.- 4. Reovirus Effects on Cytoskeletal Organization.- 5. Summary.- 6. References.- 10 Inhibition of Host Cell Macromolecular Synthesis following Togavirus Infection.- 1. Introduction.- 2. Acute Infection by Alphaviruses in Vertebrate Cell Cultures.- 3. Chronic and Persistent Infection by Alphaviruses in Vertebrate Cell Cultures.- 4. Infections by Flaviviruses in Vertebrate Cell Cultures.- 5. Infection by Togaviruses in Invertebrate Cell Cultures.- 6. Concluding Remarks.- 7. References.- Cumulative Contents.- Cumulative Author Index.- Cumulative Subject Index.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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