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OverviewPerspectives on Anti-Inflammatory Drugs Inflammation is a very complicated process of interrelated events and cas cades that does not allow for an easily defined, focused attack for drug discovery. It is evident from years of research and development that certain classes of compounds (e.g., NSAIDs, steroids, and so on) have had a meas ure of success in alleviating pain and even dampening cellularlhormonal mechanisms involved in the process. Clear, mechanism-related therapies (e.g., for arthritis) and targeted drugs (e.g., for transplantation) have not been available in the past and, in reality, research in inflammation has re lied on more phenomenological approaches for resolving symptoms or on blatant cytoreductive approaches in cases like organ transplantation. In the last decade, approaches that have revealed novel cellular pathways in which intervention is possible for lymphocyte regulation (for example, cyclosporine and FK506) and small molecular weight mediators (e.g., leu kotriene inhibitors) are now either standard therapy or will be in a short time. These latter approaches have been the result of research from the 1970s up to the present. Full Product DetailsAuthor: Vincent J. Merluzzi , Julian AdamsPublisher: Springer-Verlag New York Inc. Imprint: Springer-Verlag New York Inc. Edition: Softcover reprint of the original 1st ed. 1995 Dimensions: Width: 15.50cm , Height: 1.70cm , Length: 23.50cm Weight: 0.487kg ISBN: 9781461598480ISBN 10: 1461598486 Pages: 304 Publication Date: 05 February 2012 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of Contents1 The Discovery of Drugs to Treat Arthritis: A Historical View.- 2 The History of the Discovery and Development of Cyclosporine (Sandimmune®).- 3 Discovery and Development of FK506 (Tacrolimus), A Potent Immunosuppressant of Microbial Origin.- 4 Discovery of Sulindac, a Reversible Prodrug, as a Second-Generation Indomethacin.- 5 The Discovery of Zileuton (Leutrol®).- 6 Discovery of Accolate™ (ICI 204,219), a Peptide Leukotriene Antagonist for Asthma.- 7 Discovery of ZD2138, a Potent, Selective, Well-Tolerated, Nonredox Inhibitor of the Enzyme 5-Lipoxygenase.- 8 Development of MK 0591: An Orally Active Leukotriene Biosynthesis Inhibitor with a Novel Mechanism of Action.- 9 Discovery of BIRM 270: A New Class of Leukotriene Biosynthesis Inhibitors.- 10 Discovery and Development of the Immunomodulatory Azaspiranes.- Keyword Index.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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