Free Delivery Over $100
|
|
|||
|
||||
OverviewThe small intestine can be divided in two parts: finger-like structures called villi cover the surface of the lumen and villi are surrounded by underlying pockets termed crypts. Both structures are covered with a columnar epithelium. The crypt base harbors LGR5+ stem cells and Paneth cells. Paneth cells are playing a very important role for stem cell function by secreting essential factors like Wnt, EGF and Notch ligands, and are also involved in the antimicrobial response. It has been shown that EGF is an essential survival factor for in vitro intestinal organoid cultures. However, its precise role for in vivo stem cell function has not yet been elucidated. I employed mice lacking the EGFR in different cell types of the intestine namely Lgr5+: (1) EGFRfl/fl LGR5CreERT2EGFP mice (2) EGFRfl/fl Villin Cre mice Full Product DetailsAuthor: Göcen Vasfiye BilgePublisher: AV Akademikerverlag Imprint: AV Akademikerverlag Dimensions: Width: 15.20cm , Height: 0.70cm , Length: 22.90cm Weight: 0.168kg ISBN: 9783639856095ISBN 10: 3639856090 Pages: 108 Publication Date: 08 July 2015 Audience: General/trade , General Format: Paperback Publisher's Status: Active Availability: In stock  We have confirmation that this item is in stock with the supplier. It will be ordered in for you and dispatched immediately. Table of ContentsReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
||||
