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OverviewN-of-1 trials, a type of individualized randomized controlled trial, are relevant to almost every discipline in medicine and psychology. They can tell the clinician with precision whether a treatment works in that individual, which distinguishes from the information available from most other trial designs. They have the potential to revolutionize the way clinical medicine is practiced. Whether you are a busy clinician, a researcher or a student, this book provides everything you need to know about N-of-1 trials. Written and edited by some of the world’s leading experts on N-of-1 trials, the book presents state of the art knowledge about N-of-1 trials, with chapters on ethics, statistics, health economics, design, analysis and reporting, and more. Full of examples and well illustrated, it is a comprehensive compendium of issues surrounding the design, conduct, interpretation and implementation of N-of-1 trials in a health system. Full Product DetailsAuthor: Jane Nikles , Geoffrey MitchellPublisher: Springer Imprint: Springer Edition: Softcover reprint of the original 1st ed. 2015 Weight: 3.985kg ISBN: 9789402404401ISBN 10: 9402404406 Pages: 245 Publication Date: 23 August 2016 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of ContentsPreface.- Introduction.- What are N-of-1 trials?- N-of-1 trials in the behavioural sciences.- N-of-1 trials in medical contexts.- Aggregated N-of-1 trials.- Methodological considerations for N-of-1 trials.- Randomization, allocation concealment and blinding.- Data collection and quality control.- Individual reporting of N-of-1 trials to patients and clinicians.- Assessing and reporting adverse events.- Research ethics and N-of-1 trials.- Statistical analysis of N-of-1 trials.- The economics of N-of-1 trials.- Reporting N-of-1 trials to professional audiences.- Single patient open trials.- Systematic review and meta-analysis using N-of-1 trials.- Where are N-of-1 trials headed?- Index.ReviewsThis is a philosophical rethinking of the limitations of randomized controlled trials and the value of cross-over experiments conducted with a single patient. ... This is a book for experienced clinicians who are knowledgeable about current evidence-based treatment modalities and who can objectively recognize when to consider different options for treatment. (Vincent F. Carr, Doody's Book Reviews, January 2016) “This is a philosophical rethinking of the limitations of randomized controlled trials and the value of cross-over experiments conducted with a single patient. … This is a book for experienced clinicians who are knowledgeable about current evidence-based treatment modalities and who can objectively recognize when to consider different options for treatment.” (Vincent F. Carr, Doody’s Book Reviews, January 2016) Author InformationTab Content 6Author Website:Countries AvailableAll regions |
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