|
|
|||
|
||||
OverviewThis PhD project, directed by Dr. Kurt Nordstrm, the member of the Swedish Nobel Prize Committee, aimed to challenge a question that had long lingered in the field of bacterial cell cycle over the 20th century. Cell cycle essentially entails genome replication, condensation, partition and cell division. These events are encoded by multiple genes. The coordinated functions of these genes ensure the astonishing accuracy and rhythm of the events, reflecting precise control mechanisms. Although genetic studies with a gram-negative bacterium Escherichia coli established a cornerstone for molecular biology, mechanisms behind the cell cycle are poorly understood. This work, aimed at these mechanisms, studies roles of three genes and the proteins, IciA, MukB and SeqA, in control of the cell cycle events. This work contributes to revealing that MukB and SeqA, together with the other topoisomerases, maintain correct degree of superhelicity, which is crucial for replication initiation, replicon location, nucleoid partition, and, indirectly, cell division. Full Product DetailsAuthor: Tao Weitao , Kurt NordstromPublisher: VDM Verlag Dr. Muller Aktiengesellschaft & Co. KG Imprint: VDM Verlag Dr. Muller Aktiengesellschaft & Co. KG Dimensions: Width: 22.90cm , Height: 0.60cm , Length: 15.20cm Weight: 0.171kg ISBN: 9783639252323ISBN 10: 3639252322 Pages: 108 Publication Date: 07 May 2010 Audience: General/trade , General Format: Paperback Publisher's Status: Active Availability: In Print This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of ContentsReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |