Overview

An authoritative review of the current state-of-the-art understanding of the structure and function of the adrenergic receptor subtypes, as well as of the role played by these receptors in physiological and pathophysiological settings. Topics range from structure-function studies and the imaging of adrenergic receptors to the use of genetically altered mouse models and pharmacogenomics. Highlights include a survey of the knockout and overexpressed mouse models, a review of the new ways that adrenergic receptors can signal, and the effects of polymorphisms on clinical outcomes and on potential gene therapy applications. The side-by-side comparison of all the adrenergic receptors (a1, a2, and b) provides the reader with an excellent survey of the field, including the rationale for designing better drugs to control blood pressure and heart function.

Full Product Details

Author:   Dianne M. Perez
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   Softcover reprint of hardcover 1st ed. 2006
Dimensions:   Width: 15.20cm , Height: 2.10cm , Length: 22.90cm
Weight:   0.710kg
ISBN:  

9781617375590

ISBN 10:   1617375594
Pages:   404
Publication Date:   09 November 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Historical Perspectives.- Adrenergic Receptors.- Structure-Function.- Ligand Binding, Activation, and Agonist Trafficking.- New Signal Transduction Paradigms.- Regulation of the Cellular Localization and Trafficking of the Adrenergic Receptors.- Adrenergic Receptors in Clinical Medicine.- Imaging Adrenergic Receptors and Their Function.- Use of Fluorescent Ligands and Receptors to Visualize Adrenergic Receptors.- Localization of Adrenergic Receptor Subtypes and Transgenic Expression of Fluorescent-Tagged Receptors.- Genetically Altered Mouse Models.- The ?1-Adrenergic Receptors.- The ?2-Adrenergic Receptors.- The ?-Adrenergic Receptors.- Lessons From Overexpressed Mouse Models.- Adrenergic Receptor Signaling Components in Gene Therapy.- Pharmacogenomics.- Genetic, Molecular, and Clinical Characterization of Adrenergic Receptor Polymorphisms.- Microarray Analysis of Novel Adrenergic Receptor Functions.- Summary and Future Endeavors.- Summary and Future Endeavors.

Reviews

From the reviews: ...useful to anyone interested in adrenoceptor physiology/pharmacology or in the design of drugs interacting with the receptor or its signal transduction pathway. -Journal of Medicinal Chemistry Dianne Perez has assembled a number of important contributors to the research area and grouped the 15 chapters into six parts. ! many MDs, biologists, and pharmacologists will find the book ! appealing, as the receptor class is involved in numerous cardiovascular and pulmonary diseases. (Boris Schmidt, ChemMedChem, Issue 1, 2006)

From the reviews: ...useful to anyone interested in adrenoceptor physiology/pharmacology or in the design of drugs interacting with the receptor or its signal transduction pathway. -Journal of Medicinal Chemistry Dianne Perez has assembled a number of important contributors to the research area and grouped the 15 chapters into six parts. ... many MDs, biologists, and pharmacologists will find the book ... appealing, as the receptor class is involved in numerous cardiovascular and pulmonary diseases. (Boris Schmidt, ChemMedChem, Issue 1, 2006)

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