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OverviewA comprehensive examination of these fascinating proteins. Covers the basic molecular mechanisms of superantigen action, their structure and function, and their role in human diseases. Explains the clinical consequences of superantigen intoxication and the latest therapeutic interventions to combat superantigen toxicity. Emphasizes how newly discovered structural variations among superantigens affect their interactions with human immune cells. Most importantly, these structural and functional differences help explain the exacerbation of certain diseases and why certain superantigens are more effective in some tissues and not in others. Discusses the potential for the use of superantigens in bioterrorism. Serves as essential reading for researchers in the fields of microbiology, immunology, biotechnology, molecular medicine, and clinical infectious disease. This title is published by the American Society of Microbiology Press and distributed by Taylor and Francis in rest of world territories. Full Product DetailsAuthor: Malak Kotb , John D FraserPublisher: American Society for Microbiology Imprint: American Society for Microbiology Dimensions: Width: 18.60cm , Height: 2.20cm , Length: 26.30cm Weight: 0.906kg ISBN: 9781555814243ISBN 10: 1555814247 Pages: 292 Publication Date: 03 August 2007 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Unknown Availability: Out of stock  Table of ContentsTable of Contents Section I. Superantigens: What is New? 1. The Streptococcal Superantigens, John D. Fraser and Thomas Proft 2. Staphylococcal and Streptococcal Superantigens: an Update (Patrick M. Schlievert and Gregory A. Bohach 3. Mycoplasma arthritidis-Derived Superantigen (MAM), a Unique Class of Superantigen That Bridges Innate and Adaptive Immunity, Barry C. Cole and Hong-Hua Mu 4. Viral Superantigens in Mice and Humans, Albert K. Tai and Brigitte T. Huber 5. Superantigens from Gram-Negative Bacteria and the Diseases That They Cause, Takehiko Uchiyama, Tohru Miyoshi-Akiyama, and Hidehiro Ueshiba Section II. Superantigen Structure and Function 6. Superantigen Architecture: Functional Decoration on a Conserved Scaffold, Vickery L. Arcus and Edward N. Baker 7. Structural Evidence for Zinc and Peptide Dependence in Superantigen-Major Histocompatibility Complex Class II Interaction, Bjoern Walse 8. Superantigens: Structure, Function, and Diversity, Matthew D. Baker and K. Ravi Acharya Section III. Superantigens and Human Diseases 9. Role of Superantigens in Skin Disease, Sang-Hyun Cho and Donald Y. M. Leung Section IV. Experimental Models for Superantigen-Mediated Diseases 10. Pathogenetic Mechanisms and Therapeutic Approaches in Superantigen-Induced Experimental Autoimmune Diseases, Andrej Tarkowski 11. Experimental Models of Superantigen-Mediated Neuropathology, Malte E. Kornhuber, Alexander Emmer, Kristina Gerlach, and M. S. Staege 12. Novel Experimental Models for Dissecting Genetic Susceptibility of Superantigen-Mediated Diseases, Eva Medina Section V. Therapeutic Interventions in Superantigen-Mediated Diseases 13. Intravenous Immunoglobulin Therapy in Superantigen-Mediated Toxic Shock Syndrome, Anna Norrby-Teglund, Donald E. Low, and Malak Kotb 14. Broad-Spectrum Peptide Antagonists of Superantigen Toxins, Revital Levy, Iris Nasie, Dalia Hillman, Gila Arad, and Raymond Kaempfer 15. Small Nonpeptide Inhibitors of Staphylococcal Superantigen-Induced Cytokine Production and Toxic Shock, Teresa Krakauer 16. Countermeasures against Superantigens: Structure-Based Design of Bispecific Receptor Mimics, Goutam Gupta and Meghan KunkelReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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