Overview

This book provides more than just a comprehensive history, critical vocabulary, insightful compilation of motivations, and clear explanation of the state-of-the-art of modern clinical trial simulation. It supplies a rigorous framework for employing simulation as an experiment, according to a predefined simulation plan, that reflects good simulation practices. The book discusses: how to clinically trial designs according to their probability for success; techniques to define distributions of virtual subjects' characteristics; methods to determine the sensitivity of the trial design; and the population relationship between dosing schedules and patient response.

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9781280195136

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