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Overview"Of the porphyrinoid structures occurring in nature the most important and most widespread are the red blood pigment heme (1), the green pigment of plant photosynthesis chlorophyll a (2), the bacterial photo- synthetic pigment bacteriochlorophyll a (3), and the ""antipernicious"" red pigment vitamin BJ2 (4). The basic function of these cofactors are determined by the incorporation of the different metal ions into the macrotetracycles. The different oxidation levels of the macrocyclic ligand system regulate the fine tuning of these functions. The final adaptation of the cofactors to their special molecular environments in the cell compartments is effected by variation of the substitution patterns of the chromophores. HCO,C 3 CO,Phytyl 2 Heme Chlorophyll a CONH, CONH, ~ H,NOC 1 , CONH, /I(Y N~ 3 4 Bacteriochlorophyll a Vitamin B"" HO References, pp. 42-51 Naturally Occurring Cyclic Tetrapyrroles 3 Until the mid-1970s the four classic cyclic tetrapyrrolic structures with their porphyrin, chi orin, bacteriochlorin, and corrin skeletons were almost the only representatives in the class of porphyrinoid natural products (1-10). Although other partially reduced porphyrins were conceivable, none of these partially saturated porphyrinoid structures had hitherto been found in nature." Full Product DetailsAuthor: M. Glasenapp-Breiling , P. G. Jagtap , D. G. I. Kingston , F.-P. MontfortsPublisher: Springer Verlag GmbH Imprint: Springer Verlag GmbH Edition: Softcover reprint of the original 1st ed. 2002 Volume: 84 Dimensions: Width: 15.50cm , Height: 1.40cm , Length: 23.50cm Weight: 0.415kg ISBN: 9783709132289ISBN 10: 3709132282 Pages: 253 Publication Date: 15 June 2012 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: In Print  This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of ContentsNaturally Occurring Cyclic Tetrapyrroles.- 1. Introduction.- 2. Classification.- 3. General Aspects of Cyclic Tetrapyrrole Biosynthesis.- 4. Porphyrins.- 5. Chlorins.- 6. Bacteriochlorins.- 7. Isobacteriochlorins.- 8. Higher Saturated Hydroporphyrins.- 9. Corrins.- Acknowledgments.- References.- The Chemistry of Taxol and Related Taxoids.- 1. Introduction.- 2. A-Ring Chemistry.- 3. B-Ring Chemistry.- 4. C-Ring Chemistry.- 5. D-Ring Chemistry.- 6. Rearrangements and Related Reactions.- 7. The Side Chain.- 8. Synthesis of Taxol and Taxol Side Chain Analogs from Baccatin III.- 9. Taxol Metabolites.- 10. Taxol Analogs and Prodrugs.- 11. Labeled Taxol Analogs.- 12. The Synthesis of Taxol and Taxol Analogs from Precursors other than Baccatin III.- 13. The Synthesis of Simplified and Unusual Taxol Analogs.- 14. The Synthesis of Taxol.- 15. The Interaction of Taxol with Tubulin.- Addendum.- Acknowledgements.- References.- Author Index.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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