Overview

This is a little book with no great pretensions. The authors do not claim it to be world-startling nor Nobel- or Pulitzer-prize-winning. It is a valuable primer for pharmacokinetics for those desiring a proper initiation into previously assumed mysteries. It is fully intended as an introduction to the basic concept of pharmacokinetics and will be welcomed by all who wish to apply its principles to their own disciplines, whether in life sciences or medicine, without being confused by excess mathematics. It is edited by two well-known German scientists who are primarily practicing pediatricians and who use pharmacokinetics in their daily work, in a field of medicine where the proper adjustment of doses for infants and children is a delicate and life-preserving art. They were trained as pediatricians and as pharmacokinetists by the world-renowned Profes­ sor F. HARTMUT DOST, who uniquely synthesized these two disciplines and who, as a pioneer in this field, published the first book on pharmacokine­ tics in 1953. In their own right, the editors have conducted excellent and unique research on the effect and fate of drugs and have followed up the unexpected changes in drug action accompanying the rapid developments encountered in the initial hours, days, and weeks after birth. You will find some interesting Germanisms in this book a la Professor DOST. I personally feel that these will give some spice to their renditions.

Full Product Details

Author:   Erich Gladtke ,  E. R. Garret ,  W. Kubler ,  P. J. Wilkinson
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 1979
Weight:   0.200kg
ISBN:  

9783540091837

ISBN 10:   3540091831
Pages:   144
Publication Date:   01 April 1979
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

I. Volume of Distribution.- II. Compartments.- 1. Protein Binding.- 2. Gastrointestinal Reabsorption.- III. Elimination.- 1. Equation for Elimination.- a) Theoretical Initial Concentration.- b) Half-Time of Elimination.- c) Rate Constant of Elimination.- d) Total Clearance.- e) Saturation Kinetics.- f) Determination of Pharmacokinetic Data from Urine.- IV. Steady State.- 1. Conditions for a Steady State.- a) The Exchangeable Pool.- b) Experimental Analysis of a Natural Steady State.- c) Endogenous Transfer.- 2. Artificial Steady State - Continous Infusion.- V. Multicompartment Systems.- 1. The Model.- a) Invasion.- b) Concentration-Time Curve for Simultaneous Invasion and Elimination.- c) The Bateman Function.- 2. Dost's Principle of Corresponding Areas.- a) Test of Completeness of Invasion.- b) Rule of Corresponding Areas as a Supplement to the Basic Pharmacokinetic Experiment.- 3. Dost's Rule of Corresponding Fractional Areas.- a) Fractional Quantities and Fractional Areas.- b) Conversion of Areas to Quantities of Substance.- 4. General Consideration of Multicompartment Models.- a) Multi-Exponential Function.- b) Subdivision into Individual e-Functions.- c) Practical Importance of the C; y-Expression.- VI. Pharmacokinetics and Treatment.- 1. Repeated Administration of a Drug.- a) Duration of Accumulation.- b) Degree of Accumulation.- VII. Pharmacokinetics of Gastrointestinal Absorption.- 1. Gastrointestinal Absorption and the Bateman Function.- 2. Reconstruction of the Invasion Curves.- 3. Use of the Invasion Curves.- 4. Calculation of Dose-Proportional Absorption.- 5. Variants of the Invasion Process in Gastrointestinal Absorption.- a) Variants in the Site of Absorption.- b) Delay in Invasion Due to Lymphatic Transport of Lipid-Soluble Substances.- c) Physical and Chemical Reactions After Absorption.- d) Excretion and Reabsorption of Substances in the Intestine.- e) Limitation of the Absorptive Capacity.- f) Different Absorptive Capacity of Two Segments of Intestine.- 6. Conclusions.- 7. Appendix: Some Formulae and Their Derivation.- VIII. Interaction.- 1 Elimination.- a) Pathological Changes in the Organ of Excretion.- b) Age-Dependent Changes in Elimination.- c) Pharmacogenetic Factors.- d) Dependence of Rate of Elimination on Acid-Base Balance.- e) Circadian Rhythm of Excretion Rate.- f) Water Diuresis and Rate of Elimination.- g) Solvent Deficiency.- h) Enzyme Induction.- i) Inhibition of Elimination by Toxicity.- 2. Volume of Distribution.- a) Hydration and Dehydration.- b) Hydropic States.- 3. Conclusions.- IX. Use of Analogue Computers in Pharmacokinetics.- 1. Principle of the Analogue Computer.- 2. Programming the Analogue Computer.- 3. Use.- X. Practical Application of Pharmacokinetic Procedures.- 1. Methods of Measurement.- a) Microbiological Methods.- b) Chemical Analysis.- c) Radioactively Labelled Substances.- 2. Assessment of the Results of Animal Experiments.- 3. Derivation of Pharmacokinetic Parameters and Constants.- a) Calculation from a Graph.- b) Programmend Procedures.- 4. Mathematical Basis of Programming.- a) Distribution of a Substance Between Several Compartments.- b) Blood Concentration-Time Curves for Pure Invasion.- c) Blood Concentration-Time Curves for Pure Elimination.- d) Blood Concentration-Time Curves for Simultaneous Invasion and Elimination (Batemann Function).- e) Accumulation, Limiting Curve.- f) Dosage Scheme.- 5. Examples of Calculation.- Further Reading.

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