Overview

Pharmacogenetics, Kinetics, and Dynamics for Personalized Medicine provides a primer to understand pharmacogenetics (the study of genetic factors that influence how a drug works) in the applied context of pharmacokinetics (how the body handles a drug) and pharmacodynamics (the effects of a drug on the body). This valuable foundation illuminates how these principles and scientific advances can create optimal individual patient care, that is, 'personalized medicine.' Through specific drug examples, this resource explores how the genetic constitution of an individual may lead to the need for an altered dose or in some cases alternative drug therapy. Real-world cases highlight the specific relationships between genetics, drug action, and the body's response as well as adverse drug reactions, altered metabolism, and drug efficacy. Ethical issues concerning pharmacogenomics and study design are also discussed in this concise overview.

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9781449652739

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Dr. Kisor is Professor and Chair of the Department of Pharmaceutical and Biomedical Sciences at the Raabe College of Pharmacy at Ohio Northern University. Kisor received his Bachelor of Science degree in Pharmacy from the University of Toledo and his Pharm. from The Ohio State University. He completed a fellowship in Therapeutic Drug Monitoring and Pharmacokinetics at Ohio State. Kisor came to ONU from Burroughs Wellcome Co., now GlaxoSmithKline, where he was a research scientist in Pharmacokinetics & Drug Metabolism, working mostly on the development of purine analog anti-leukemia drugs, including the drug nelarabine, a derivative of guanine, one of the “building blocks of life”, that was marketed in the U.S. in 2005. His focus at ONU has been teaching pharmacokinetics and relating genetics to pharmacokinetics. He has integrated pharmacogenetics into the pharmacokinetic subject matter since 1998. He is a member of the American Pharmacists Association (APhA), the American Association of Colleges of Pharmacy (AACP), the National Coalition for Healthcare Provider Education in Genetics (NCHPEG), and the Personalized Medicine Coalition (PMC) and is the advisor for the ONU Student Chapter of the PMC. Dr. Kane’s professional experience includes preclinical research in the pharmaceutical industry, Vice President of Research and Development at a publicly-traded genomics/biotechnology company, and co-founding several companies based on technology and methods that he has developed/patented. His primary interests have involved the development and utilization of genomic detection technologies, primarily DNA microarray methods, which have been applied to exploratory discovery efforts in agriculture, ecological, preclinical and clinical studies. In addition, he has led the efforts to develop data management tools in support of pharmacogenomics and personalized medicine, which have been extensively utilized as a teaching tool for healthcare professionals. Dr. Kane also serves as an expert witness in criminal cases involving DNA evidence. Dr. Sprague is a Professor of Pharmacology and Dean at the Raabe College of Pharmacy at Ohio Northern University. Before returning to ONU as Dean in 2006, Dr. Sprague was Professor and Chair of Pharmacology at the Virginia College of Osteopathic Medicine at Virginia Tech University. He received his PhD in Pharmacology and Toxicology from Purdue University and his Pharmacy degree from Ferris State University. His research interests include studying the hyperthermic mechanisms of the substituted amphetamines, namely 3,4-methylene-dioxy-meth-amphetamine (MDMA, Ecstasy). One of Dr. Sprague’s major professional priorities is to assist in the implementation of personalized medicine to improve health outcomes. Dr. Talbot received a Bachelor of Science degree in Biochemistry from the University of Nevada. He went on to earn a PhD in Pharmacology from the University of Nebraska Medical Center, utilizing yeast genetics to identify and characterize novel regulators of G protein-coupled receptors in the central nervous system. Talbot continued his studies as a National Institute on Drug Abuse (NIDA) research fellow at the University of Michigan Medical School, where he investigated the effects of transgene-mediated mutations on neurotransmitter function in mouse genetic models. At the Raabe College of Pharmacy at Ohio Northern University, Talbot teaches fourth-and fifth-year pharmacy students on topics including neuronal communications, drug action in the central nervous system and genetic influence on drug responses. He also directs pre-clinical research utilizing genetically modified mice to explore novel treatments for drug abuse and depression.

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