Overview

Protein-protein interactions are involved in muscle contraction and signal transduction. This book describes how synthetic peptides may be used, much like antibodies, both as specific inhibitors and as molecular probes to explore the cognitive interfaces between interacting proteins and their functional significance. This offers the prospect of very selective intervention in cellular mechanisms. These timely contributions by several experts will appeal to the researchers in muscle physiology, cardiovascular pharmacology and cell biology who are interested in this new approach.

Full Product Details

Author:   Johann C. Rüegg
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 1991
Dimensions:   Width: 15.50cm , Height: 1.00cm , Length: 23.50cm
Weight:   0.295kg
ISBN:  

9783642764110

ISBN 10:   3642764118
Pages:   174
Publication Date:   21 December 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Structure of Actin.- Interaction of Actin 1–28 with Myosin and Troponin I and the Importance of these Interactions to Muscle Regulation.- Probing Myosin Head Structures with Monoclonal Antibodies and Recombinant Technology.- An Actin-Binding Site on Myosin.- Competitive Inhibition of Maximum Ca-Activated Force in Skinned Muscle Fibers by Cationic Peptides from the SH-1 Region of Myosin Heavy Chain.- The Use of Peptide Mimetics to Define the Actin-Binding Sites on the Head of the Myosin Molecule.- Interference of Myosin Peptides with Weak and Strong Actin Interaction of Cross-Bridges in Skeletal Muscle Fibres.- Caldesmon Derived Polypeptides as Probes of Force Production in Skeletal Muscle.- Myosin and Troponin Peptides Affect Calcium Sensitivity of Skinned Muscle Fibres.- Peptides as Probes of the Mechanisms Regulating Smooth Muscle Contractility: Studies on Skinned Fibres.- Antibodies as Probes of the Mechanisms Regulating Smooth Muscle Contractility: Studies on Skinned Fibres.- Regulation of Ca2+ Release from Sarcoplasmic Reticulum of Skeletal Muscle by an Endogenous Substance.- Defining Sites and Mechanisms of Interaction Between Rhodopsin and Transducin.- Comparative Studies on Chicken Skeletal and Smooth Muscle Dystrophins.- Use of Synthetic Peptides in the Study of the Function of Dystrophin.

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