Overview

This two-volume treatise, the collected effort of more than 50 authors, represents the first comprehensive survey of the chemistry and biology of the set of molecules known as peptide growth factors. Although there have been many symposia on this topic, and numerous publications of reviews dealing with selected subsets of growth factors, the entired field has never been covered in a single treatise. It is essential to do this at the present time, as the number of journal articles on peptide growth factors now makes it almost im­ anyone person to stay informed on this subject by reading the possible for At the same time it is becoming increasingly apparent that primary literature. these substances are of universal importance in biology and medicine and that the original classification of these molecules, based on the laboratory setting of their discovery, as ""growth factors,"" ""lymphokines,"" ""cytokines,"" or ""colony-stimulating factors,"" was quite artifactual; they are in fact the basis of a common language for intercellular communication. As a set they affect es­ sentially every cell in the body, and in this regard they provide the basis to develop a unified science of cell biology, germane to all of biomedical research.

Full Product Details

Author:   Michael B. Sporn ,  Anita B. Roberts
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 1990
Volume:   95 / 2
Dimensions:   Width: 15.50cm , Height: 3.80cm , Length: 23.50cm
Weight:   1.136kg
ISBN:  

9783642747830

ISBN 10:   3642747833
Pages:   727
Publication Date:   21 December 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Section B: Individual Growth Factors and Their Receptors (Cont’d from Part I).- 19 Interferons.- 20 Cachectin/Tumor Necrosis Factor and Lymphotoxin.- 21 Bombesin and Gastrin-Releasing Peptide: Neuropeptides, Secretogogues, and Growth Factors.- 22 Platelet-Derived Endothelial Cell Growth Factor.- 23 Nerve Growth Factor.- 24 A Glia-Derived Nexin Acting as a Neurite-Promoting Factor.- 25 Mullerian Inhibiting Substance.- 26 The Inhibin/Activin Family of Hormones and Growth Factors.- 27 Mammary-Derived Growth Inhibitor.- 28 Pentapeptide Growth Inhibitors.- Section C: Coordinate Actions of Growth Factors in Specific Tissues or Cells.- 29 Coordinate Actions of Hematopoietic Growth Factors in Stimulation of Bone Marrow Function.- 30 Peptide Growth Factors and the Nervous System.- 31 Role of Growth Factors in Cartilage and Bone Metabolism.- 32 Role of Lymphokines in the Immune System.- 33 Coordinate Actions of Growth Factors in Monocytes/Macrophages.- 34 Extracellular Matrices, Cells, and Growth Factors.- Section D: Processes Regulated by Growth Factors.- 35 Induction of Proteases and Protease Inhibitors by Growth Factors.- 36 Inflammation and Repair.- 37 Angiogenesis.- 38 Metastasis.- 39 Expression of Growth Factors and Their Receptors in Development.- 40 Relationships Between Oncogenes and Growth Control.- Appendix A. Alternate Names for Growth Factors.- Appendix B. Chromosomal Locations of Growth Factors/Growth Factor Receptors.

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