Overview

It has been known for a number of years that not only pathogenicity islands but also plasmids and bacteriophages are able to carry genes whose products are involved in pathogenic processes. Accordingly, such elements and their products play an important role in pathogenesis due to the intestinal E. coli as well due to Shigellae. Another interesting aspect which is reflected in different articles is that genomes evolve by acquisition of new pieces of DNA following gene transfer, but also by genome reduction. Different mechanisms include the deletion of sequences or the elimination of functions by the accumulation of point mutations or rearrangements.

Full Product Details

Author:   J. Hacker ,  J.B. Kaper
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of hardcover 1st ed. 2002
Volume:   264/1
Weight:   0.396kg
ISBN:  

9783642076565

ISBN 10:   3642076564
Pages:   234
Publication Date:   01 December 2010
Audience:   Professional and scholarly ,  Professional and scholarly ,  Professional & Vocational ,  Postgraduate, Research & Scholarly
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

List of Contents.- Evolution of Prokaryotic Genomes.- Extraintestinal Escherichia coli as a Model System for the Study of Pathogenicity Islands.- Pathogenicity Islands of Intestinal E. coli.- Pathogenicity Islands of Shigella.- Pathogenicity Islands and Host Adaptation of Salmonella Serovars.- Plasmids and Pathogenicity Islands of Yersinia.- Genomic Organization of LPS-Specific Loci.- Genomic Structure of Capsular Determinants.- Genome Plasticity in Pathogenic and Nonpathogenic Enterobacteria.- Phylogenetic Relationships and Virulence Evolution in the Genus Bordetella.- Pathogenicity Islands and PAI-Like Structures in Pseudomonas Species.

Reviews

From the reviews: In addition to classic mutational events, a highly successful strategy of generating genetic diversity in bacteria is the acquisition of genomic islands. ! This compendium ! features an international assembly of authors including W. Arber (Basel) giving a lucid introduction into the evolution of prokaryotic genomes. The two-volume work provides a comprehensive overview of the current state of knowledge on PAIs and other mobile virulence determinants in bacterial as well as fungal pathogens of humans and plants. (Susanne Rohrer, BioWorld, Issue 6, 2002)

From the reviews: In addition to classic mutational events, a highly successful strategy of generating genetic diversity in bacteria is the acquisition of genomic islands. ... This compendium ... features an international assembly of authors including W. Arber (Basel) giving a lucid introduction into the evolution of prokaryotic genomes. The two-volume work provides a comprehensive overview of the current state of knowledge on PAIs and other mobile virulence determinants in bacterial as well as fungal pathogens of humans and plants. (Susanne Rohrer, BioWorld, Issue 6, 2002)

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