Overview

Development of new-generation vaccines is now more challenging than ever, as identifying, purifying and evaluating vaccine antigens is a complex undertaking. Most importantly, once the relevant antigens have been identified, key focus then shifts to the development of suitable delivery systems and formulations to achieve maximum in vivo potency with minimum potential side effects. These novel formulations—many of which will be nanoparticulates—can deliver the antigens to the desired site, to the relevant antigen presenting cells, and prevent systemic exposure of the immune potentiators. The proposed book will outline all the critical steps that need to be considered for successful development of various types of nanoparticulate delivery systems for vaccine antigens. These contributions from leading experts in the area of vaccine formulation and delivery systems will tie in what is the most current status, including clinical evaluations with these novel vaccine technologies.​

Full Product Details

Author:   Manmohan Singh
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   2013 ed.
Dimensions:   Width: 15.50cm , Height: 2.00cm , Length: 23.50cm
Weight:   5.737kg
ISBN:  

9781489992284

ISBN 10:   1489992286
Pages:   370
Publication Date:   28 January 2015
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Critical parameters that govern the optimization of vaccine formulations.- Development of Biophysical assays to better understand vaccine formulation stability.- Rational design of vaccine formulations.- Monitoring stability and efficacy of multi-valent vaccine formulations.-  Overcoming challenges of multi component alum formulations.-  Delivery of various TLR adjuvants using alum platform.- History of use of emulsions for vaccine delivery.- MF59 o/w emulsion : History and safety over the last 2 decades.- Optimizing novel nanoemulsions for delivery of next generation antigens and adjuvants.- Modulating vaccine responses with innate immunity : Use of PLGA nanoparticles for delivering multiple TLR agonists.- Shape matters : Role of nanoparticle shape in induction of immune responses to a vaccine.        

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