Overview

This book presents a selection of the most recent approaches for the production of novel biotechnological compounds for biomedical applications. In order to better focus on the challenges at hand, the Editors have striven to adopt an integrative approach by selecting contributions linking genomics with bacterial resistance, antibiotics with improved production strategies, optimised production approaches with chemical development programs, chemical modifications with new antibody derivatives and biomaterials, the relation between bioartificial organs and xenotransplantation, apoptosis and process biotechnology, etc. The different chapters provide an interesting overview of the current state of the art in the development of truly novel compounds for biomedical application using recombinant DNA approaches. This book will be of interest to academic and industrial scientists dealing with biomedical sciences and for teachers who want to be informed about the latest developments in the field.

Full Product Details

Author:   A. van Broekhoven ,  Fred Shapiro ,  Jozef Anné
Publisher:   Springer
Imprint:   Springer
Edition:   Softcover reprint of the original 1st ed. 2001
Volume:   1
Dimensions:   Width: 15.50cm , Height: 2.30cm , Length: 23.50cm
Weight:   0.706kg
ISBN:  

9789048156283

ISBN 10:   9048156289
Pages:   454
Publication Date:   04 December 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Genomics: the New Approach to the Discovery of New Compounds.- The Genomics Approach: Is it Really the Solution?.- The Contribution of Genomics to the Discovery of New Antibiotics.- Antibiotics.- The Antibiotic Gallidermin-Evolution of a Production Process.- Resistance to ?-Lactams, a Self-Regenerating Problem.- Resistance to aminoglycoside Antibiotics: Function meets structure.- The Genetics and Biochemistry of Resistance to Glycopeptide Antibiotics.- ?-Lactamases, an Old but Ever Renascent Problem.- Metabolic Flux Analysis in Streptomyces Coelicolor: Effect of nitrogen source.- Metabolic Engineering of the Lysine Pathway for ?-Lactam Overproduction in Penicillium Chrysogenum.- Glycosylation of Antibiotics and Other Agents from Actinomycetes.- Enzymatic Synthesis of Amoxicillin.- Production of Therapeutic Antibodies.- New Recombinant Bi- and Trispecific Antibody Derivatives.- Advantages of Single-Domain Antigen-Binding Fragments Derived from Functional Camel Heavy-Chain Antibodied.- Heterologous Protein Production: New Production Strategies.- Furin as a Tool for the Endoproteolytic Maturation of Susceptible Recombinant Biopharmaceuticals.- Development of Bioprocesses for the Generation of Anti-Inflammatory, Anti-Viral and Anti-Leukaemic Agents.- Apoptosis and Bioprocess Technology.- Gram-Positive Bacteria as Host Cells for Heterologous Production of Biopharmaceuticals.- Multiple Pathways of Exoprotein Secretion in Gram-Negative Bacteria.- Alteration of Metabolic Flux Distributions in Recombinant Escherichia Coli in Response to Heterologous Protein Production.- Dynamics of Proteolysis and its Influence on the Accumulation of Intracellular Recombinant Protein.- Artificial Organs and Xenografting.- The Impact of Transgenesis and Cloning on Cell and OrganXenotransplantation to Humans.- Reinforced Bioartificial Skin in the Form of Collagen Sponge and Threads.- Antitumour Compounds.- Towards the Generation of Novel Antitumour Agents from Actinomycetes by Combinational Biosynthesis.- Cell Immobilisation of Taxus Media.- Pre and Probiotics.- The Role of Prebiotics in Human Gut Microbiology.- The Influence of Intestinal Microflora on Mucosal and Systemic Immune Responses.

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