Overview

The problems associated with the pharmacologic and physiologic regulation of neuromuscular transmission and of the morphofunctional organization of neuromuscular junctions have attracted a wide range of investigators. Numerous handbooks, monographs, and reviews are devoted to this subject. At the same time, many fundamental and applied aspects of this trend continue to progress succesfully. In recent years, new experimental and clinical data on the structure and function of neuromuscular junctions have been gained, and new, more perfect neuromuscular blocking agents have been designed. It is these data that the present handbook mainly deals with. A considerable number of chapters have been written by authors from eastern Europe. This was done intentionally since much of their work has previously been published only in their own languages, and is thus inaccessible to most Western readers. This is why some of the data included in the volume are not quite the latest, but they contain fruitful ideas or important results and are of value for further progress in the pharmacology of neuromuscular transmission. Naturally, the methodological level of the investigations differs, depending on when they were carried out. The handbook contains a number of selected chapters on the pharmacology of neuromuscular junctions; they comprise data otherwise insufficiently reviewed or not dealt with at all. They furthermore reflect the up-to-date state of the problem and probable directions of further developments in this field. D. A. KHARKEVICH Contents CHAPTER 1 Neuromuscular Blocking Agents: General Considerations D. A. KHARKEVICH . . . . . . . . . . . . . . . .

Full Product Details

Author:   Dimitry A. Kharkevich ,  S. Agoston
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 1986
Volume:   79
Dimensions:   Width: 17.00cm , Height: 3.90cm , Length: 24.40cm
Weight:   1.306kg
ISBN:  

9783642706844

ISBN 10:   3642706843
Pages:   744
Publication Date:   13 December 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

1 Neuromuscular Blocking Agents: General Considerations.- 2 The End-Plate Acetylcholine Receptors: Structure and Function.- A. Introduction.- B. Molecular Properties of the Acetylcholine Receptor.- C. The 43K Protein.- D. Multiple Binding Sites and Multiple Affinity States.- E. Three-Dimensional Structure.- F. Biochemical Control Over Receptor Activity: Phosphorylation, Methylation, and Glycosylation.- G. Summary and Conclusions.- References.- Pharmacodynamics and Pharmacokinetics of Neuromuscular Blocking Agents.- 3 On the Principles of Postsynaptic Action of Neuromuscular Blocking Agents.- 4 On the Hydrophobic Interaction of Neuromuscular Blocking Agents with Acetylcholine Receptors of Skeletal Muscles.- 5 Prejunctional Actions of Cholinoceptor Agonists and Antagonists, and of Anticholinesterase Drugs.- 6 On the Comparative Sensitivity of Acetylcholine Receptors of Various Groups of Skeletal Muscles to Neuromuscular Blocking Agents.- 7 Antimuscarinic and Ganglion-Blocking Activity of Neuromuscular Blocking Agents.- 8 The Interaction of Neuromuscular Blocking Agents With Human Cholinesterases and Their Binding to Plasma Proteins.- 9 On the Effect of Neuromuscular Blocking Agents on the Central Nervous System.- 10 Biodegradation and Elimination of Neuromuscular Blocking Agents.- On the Relationship Between the Chemical Structure and the Neuromuscular Blocking Activity.- 11 Methods for the Experimental Evaluation of Neuromuscular Blocking Agents.- 12 Steroid Derivatives.- 13 The Derivatives of Carboxylic Acids.- 14 Quinuclidinium Compounds.- 15 Derivatives of Terphenyl..- 16 Delphinium Alkaloids.- Preclinical Pharmacology of New Neuromuscular Blocking Drugs.- 17 Bisquaternary Steroid Derivatives.- 18 Vecuronium (ORG-NC-45).- 19 The Derivatives of ?-Truxillic Acid.- 20Adamantyl Compounds.- 21 Tercuronium..- 22 Dioxonium..- 23 Fazadinium Dibromide..- 24 Atracurium.- Clinical Pharmacology of New Neuromuscular Blocking Drugs.- 25 General Principles and Methods of Evaluation of Neuromuscular Blocking Agents in Anesthesiology.- 26 Neuromuscular Blocking Agents of Different Chemical Structure.- 27 Pipecuronium Bromide (Arduan)..- 28 Vecuronium (ORG-NC-45)..- 29 Fazadinium Dibromide.- 30 Atracurium.- Antagonists of Neuromuscular Blocking Agents (Pharmacology and Clinical Use).- 31 Galanthamine..- 32 Chinothylinum..- 33 4-Aminopyridine Hydrochloride (Pymadin).- Subject Index V.V. Maisky.

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