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9781849736381

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"""The book chapters are nicely and logically organised starting from fabrication to theory, applications, and finishing with the latest developments in microfluidics...The book is well suited for those readers new to the field of microfluidics as well as for those who want to dive deeper in specific aspects for their use in detection science."" -- Edwin Jager, Linköping University * Biosensors & Bioelectronics * Microfluidics or lab‐on‐a‐chip has the objective of integrating all or major steps of a chemical or biochemical analysis in a single device or chip. This includes sample preparation, amplification and purification, sample/fluid manipulation and finally sample detection and analysis, all merged on a single chip. These chips are intended for single use and to simplify analysis, for instance to allow for fast and direct analysis at a doctor’s office. Although a fully integrated lab‐on‐a‐chip, that is having all components from pumps to detectors on‐chip, has yet not been commercialised, many commercial examples exist where such chips are used in an external readers, thus reducing the need of sending samples to a centralised laboratory. This book “Microfluidics in detection Science ‐ Lab‐on‐a‐chip Technologies” is the fifth title in the RSC Detection Science Series edited by Prof Thompson and Drs Reddy and Arrigan, and is intended as an introduction to the field of microfluidics. The book starts (Ch. 1 Materials and Fabrication Techniques for Nano‐ and Microfluidics) with a concise introduction to the various materials and fabrication processes that have been used over the years to fabricate lab‐on‐a‐chip devices. These are illustrated by application examples. The chapter explains technologies ranging from classical silicon microfabrication methods to current polymer and glass methods, including soft lithography, and finishes with an up to date description of the latest paper‐based microfluidic technology. All sections are richly illustrated with figures. An introduction to microfluidics is not complete without providing a theoretical understanding for the reader, which is needed to properly design microfluidic devices. This is provided in Ch.2 Microfluidics Theory and Practice. This chapter introduces important concepts that arise when downscaling fluidics to the micro‐ and nano‐domains, such as laminar flow. Starting from the basic Navier‐Stokes equations, Reynolds number, Poiseuille flow and Stokes flow are introduced. Capillary forces, diffusion and the issues of (non‐)mixing, that are important aspects in microfluidics, are treated next. The chapter finishes with some applications. and application examples. Ch.5 Manipulation of Micro‐/Nano‐Objects via Surface Acoustic Waves is a relatively short chapter, but is still gives a concise explanation of the principles of generating a surface acoustic wave and how -- Dr Edwin Jager, Linköping University * Biosensors & Bioelectronics *"

The book chapters are nicely and logically organised starting from fabrication to theory, applications, and finishing with the latest developments in microfluidics...The book is well suited for those readers new to the field of microfluidics as well as for those who want to dive deeper in specific aspects for their use in detection science. -- Edwin Jager, Linkoeping University * Biosensors & Bioelectronics * Microfluidics or lab-on-a-chip has the objective of integrating all or major steps of a chemical or biochemical analysis in a single device or chip. This includes sample preparation, amplification and purification, sample/fluid manipulation and finally sample detection and analysis, all merged on a single chip. These chips are intended for single use and to simplify analysis, for instance to allow for fast and direct analysis at a doctor's office. Although a fully integrated lab-on-a-chip, that is having all components from pumps to detectors on-chip, has yet not been commercialised, many commercial examples exist where such chips are used in an external readers, thus reducing the need of sending samples to a centralised laboratory. This book Microfluidics in detection Science - Lab-on-a-chip Technologies is the fifth title in the RSC Detection Science Series edited by Prof Thompson and Drs Reddy and Arrigan, and is intended as an introduction to the field of microfluidics. The book starts (Ch. 1 Materials and Fabrication Techniques for Nano- and Microfluidics) with a concise introduction to the various materials and fabrication processes that have been used over the years to fabricate lab-on-a-chip devices. These are illustrated by application examples. The chapter explains technologies ranging from classical silicon microfabrication methods to current polymer and glass methods, including soft lithography, and finishes with an up to date description of the latest paper-based microfluidic technology. All sections are richly illustrated with figures. An introduction to microfluidics is not complete without providing a theoretical understanding for the reader, which is needed to properly design microfluidic devices. This is provided in Ch.2 Microfluidics Theory and Practice. This chapter introduces important concepts that arise when downscaling fluidics to the micro- and nano-domains, such as laminar flow. Starting from the basic Navier-Stokes equations, Reynolds number, Poiseuille flow and Stokes flow are introduced. Capillary forces, diffusion and the issues of (non-)mixing, that are important aspects in microfluidics, are treated next. The chapter finishes with some applications. and application examples. Ch.5 Manipulation of Micro-/Nano-Objects via Surface Acoustic Waves is a relatively short chapter, but is still gives a concise explanation of the principles of generating a surface acoustic wave and how -- Dr Edwin Jager, Linkoeping University * Biosensors & Bioelectronics *

The book chapters are nicely and logically organised starting from fabrication to theory, applications, and finishing with the latest developments in microfluidics...The book is well suited for those readers new to the field of microfluidics as well as for those who want to dive deeper in specific aspects for their use in detection science. -- Edwin Jager, Linkoping University Biosensors & Bioelectronics Microfluidics or lab-on-a-chip has the objective of integrating all or major steps of a chemical or biochemical analysis in a single device or chip. This includes sample preparation, amplification and purification, sample/fluid manipulation and finally sample detection and analysis, all merged on a single chip. These chips are intended for single use and to simplify analysis, for instance to allow for fast and direct analysis at a doctor's office. Although a fully integrated lab-on-a-chip, that is having all components from pumps to detectors on-chip, has yet not been commercialised, many commercial examples exist where such chips are used in an external readers, thus reducing the need of sending samples to a centralised laboratory. This book Microfluidics in detection Science - Lab-on-a-chip Technologies is the fifth title in the RSC Detection Science Series edited by Prof Thompson and Drs Reddy and Arrigan, and is intended as an introduction to the field of microfluidics. The book starts (Ch. 1 Materials and Fabrication Techniques for Nano- and Microfluidics) with a concise introduction to the various materials and fabrication processes that have been used over the years to fabricate lab-on-a-chip devices. These are illustrated by application examples. The chapter explains technologies ranging from classical silicon microfabrication methods to current polymer and glass methods, including soft lithography, and finishes with an up to date description of the latest paper-based microfluidic technology. All sections are richly illustrated with figures. An introduction to microfluidics is not complete without providing a theoretical understanding for the reader, which is needed to properly design microfluidic devices. This is provided in Ch.2 Microfluidics Theory and Practice. This chapter introduces important concepts that arise when downscaling fluidics to the micro- and nano-domains, such as laminar flow. Starting from the basic Navier-Stokes equations, Reynolds number, Poiseuille flow and Stokes flow are introduced. Capillary forces, diffusion and the issues of (non-)mixing, that are important aspects in microfluidics, are treated next. The chapter finishes with some applications. and application examples. Ch.5 Manipulation of Micro-/Nano-Objects via Surface Acoustic Waves is a relatively short chapter, but is still gives a concise explanation of the principles of generating a surface acoustic wave and how -- Dr Edwin Jager, Linkoping University Biosensors & Bioelectronics

Author Information

Dr. Sub Reddy (C.Chem. MRSC) obtained his first class degree in Chemistry from the University of Manchester. He received his Ph.D. in Membrane-based Electrochemical Biosensing from the same University (1996). His post-doctoral research interests have included the development of quartz crystal-based biosensors, operating in the liquid phase (University of Wales, Bangor; 1994-1997) and the development of application-specific odour sensors (UMIST, Manchester; 1997-1998). Dr. Reddy was Senior Lecturer in Applied Analytical Chemistry at the University of Surrey and recently moved to the University of Central Lancashire as Senior Lecturer in Analytical Chemistry. Current research interests include the development of smart, permselective and biocompatible molecular imprinted polymers and membrane materials for the sensor/sample interface and the advancement of smart materials-based electrochemical, quartz crystal and optical sensors for medical, food and environmental applications. He is particularly interested in developing hydrogel-based molecularly imprinted polymers (HydroMIPs) for the determination of protein markers and other biomarkers and construction of biosensors.

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