Overview

A NATO Advanced Research Workshop on Methods and Mechanisms for Producing Ions from Large Molecules was held at Minaki Lodge, Minaki, Ontario, Canada, from 24 to 28 June 1990. The workshop was hosted by the time-of-flight group of the Department of Physics at the University of Manitoba, and was attended by 64 invited participants from around the world. Twenty-nine invited talks were given and 19 papers were presented as posters. Of the 48 contributions, 38 are included in these proceedings. The conference was organized to study the rapidly changing field of mass spectrometry of biomolecules. Particle-induced desorption (especially with MeV particles) has been the most effective method of producing molecular ions from biomolecules. An important part of the workshop was devoted to recent developments in this field, particularly to progress in understanding the fundamentals of the desorption process. In this respect, the meeting was similar to previous conferences in Marburg, FRG (1978); Paris, F (1980); Uppsala, S (1981); College Station, USA (1983,1984); Wangerooge, FRG (1986); Orsay, F (1988); Spiekeroog, FRG (1989); and to the IFOS series of meetings at Munster, FRG (1981,1983,1985,1987) and L6vAnger, S (1989). As in the most recent of these meetings, there was some emphasis on new developments, particularly cluster bombardment. A departure from the concentration on particle bombardment processes at this conference was inspired by the dramatic results obtained with two new methods for producing molecular ions from large molecules: matrix-assisted laser desorption and electrospray.

Full Product Details

Author:   K.G. Standing ,  W. Ens
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of the original 1st ed. 1991
Volume:   269
Dimensions:   Width: 17.80cm , Height: 1.80cm , Length: 25.40cm
Weight:   0.662kg
ISBN:  

9781468479287

ISBN 10:   1468479288
Pages:   344
Publication Date:   11 December 2012
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

The Founding Fathers of Mass Spectroscopy.- MeV Particle Bombardment.- Plasma Desorption Mass Spectrometry — Achievements and Frontiers.- A New Concept: The Fast Preequilibrium Charge State of Swift Ions in Solids.- PDMS With Volatile Organic Compounds.- Competitive Peptide Adsorption to Nitrocellulose Covered Backing Material in Cf-252-Plasma Desorption Mass Spectrometry.- Charting of Rat Pituitary Peptides by Plasma Desorption and Electrospray Ionization Mass Spectrometry.- Energy and Angular Distributions of Secondary Ions Ejected from Clean Metals by MeV Ion Impact.- Different Mechanisms of Negative Ion Formation Observed with Chlorophyll-a.- Sequence Informative Fragmentation in 252Cf Plasma Desorption Mass Spectrometry.- MeV Bombardment: Theory.- Ion Formation in Electronic Sputtering from Decane.- Spatial Distribution of Biomolecules Sputtered Under Fast Heavy Ion Bombardment.- Heavy-Ion and Laser-Pulse-Induced Ejection of Large Organic Molecules.- keV Particle Bombardment.- Experimental Observations of Particle Emission from Liquid Organic Matrices Bombarded by keV Ions.- Evaluation of Secondary Ion Internal Energy Distribution in LSIMS.- Cluster Ion Emission From Cesium Chloride Bombarded with Atomic and Molecular Ions.- Negative Secondary Ion Mass Spectrometry of Gold Surfaces.- Sequencing an Unknown Peptide.- Sensitivity Measurements for Parent and Daughter Ions of Peptides in a Reflecting Time-of-Flight Mass Spectrometer.- keV Bombardment: Theory.- Stopping and Scattering of Slow Cluster Ions.- Molecular Dynamics Simulation of Bulk Desorption.- Spray Ionization Methods.- On the Mechanisms Involved in Spray Ionization.- Electrospray, Mechanism and Performance.- Optical Studies of Electrohydrodynamic Disintegration of Liquids in EH and ES Mass Spectrometry.-Electrohydrodynamic Mass Spectrometry: How High Can It Go?.- Electrospray Ionization Mass Spectrometric Analysis of Proteins.- Laser Desorption.- Laser Desorption Mass Spectrometry — Some Technical and Mechanistic Aspects.- Matrix — Assisted UV Laser Desorption with a Time Digitizer.- Investigations of Matrix Isolated, (UV) Laser Induced Polymer Sublimation Using a Time-of-Flight Mass Spectrometer.- On the Detectability of Low Velocity High Mass Ions in Matrix Assisted Laser Desorption TOF-MS.- Matrix-Assisted Laser Desorption Fourier Transform Mass Spectrometry for Biological Compounds.- Laser Induced Desorption of Atoms from Metal Particles: Mechanism and Applications.- Laser Desorption: Theory.- On the Mechanism of Volatilization of Large Biomolecules by Pulsed Laser Ablation of Frozen Aqueous Solutions.- Laser Desorption of Large Molecules: Mechanisms and Models.- Macromolecule Desorption from the Film Back Side Under Laser Irradiation.- Post — Ionization of Desorbed Neutrals.- Post-Ionization of Laser-Desorbed Organics by Single-Photon Ionization.- Laser-Induced Resonance Enhanced Multiphoton Ionization in Supersonic Beams.- Laser Desorption/Photoionization Time-of-Flight Mass Spectrometry of Polymer Additives.- Laser Desorption and Laser Post-Ionization Time-of-Flight Mass Spectrometry.- Participants.

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